双歧三联活菌片与小儿止泻安颗粒对急性腹泻患儿血清IL-7、心肌酶及同工酶水平的影响

A Study on the Effect of Bifid Triple Viable Tablets Combined with Xiao'er Zhixie'an Granule on the Serum IL-7 and Myocardial Enzyme and Isoenzyme Levels of Children with Acute Diarrhea

目的:探讨双歧三联活菌片联合小儿止泻安颗粒对小儿急性腹泻患儿血清IL-7、心肌酶及同工酶水平的影响。方法:收集我院就诊的120例小儿急性腹泻患者,随机分为实验组和对照组,每组60例。对照组患者给予双歧三联活菌片口服治疗;实验组在对照组基础上给予小儿止泻安颗粒口服治疗。观察并比较两组患者治疗前后血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、白介素-7(IL-7)以及临床治疗有效率。结果:与治疗前相比,两组患者治疗后AST、ALT、LDH、CK、CK-MB水平均显著下降,IL-7水平明显升高,差异具有统计学意义(P<0.05);与对照组相比,实验组患者的血清AST、ALT、LDH、CK、CK-MB水平较低,IL-7水平较高,差异具有统计学意义(P<0.05);与对照组相比,实验组患者的临床治疗有效率较高,差异具有统计学意义(P<0.05)。结论:双歧三联活菌片联合小儿止泻安颗粒能够降低小儿急性腹泻患者血清心肌酶、同工酶水平,升高IL-7水平,临床疗效较好。

Objective： To investigate the effect of Bifid Triple Viable tablets combined with Xiao＇er Zhixie＇an Granule on the serum IL-7, myocardial enzyme and isoenzyme levels of children with acute diarrhea. Methods： 120 cases of children with acute diarrhea in our hospital were randomly divided into the experimental group and control group, with 60 cases in each group. The control group was treated with Bifid Triple Viable tablets, 3 tablets each time, 3 times/d; in the experimental group was given Xiao＇er Zhixie＇an Granule based on the control group, oral, 12 g/time, 2 times/d, continuous 7d treatment, during the treatment, close observation of patients, timely adjust the dosage. The serum aspartate aminotransferase （AST）, alanine aminotransferase （ALT）, lactate dehydrogenase （LDH）, creatine kinase （CK）, creatine kinase isoenzyme （CK-MB） and interleukin -7 （IL-7） and clinical treatment efficienc before and after treatment were observed and compared between the two groups. Results： Compared with before treatment, the AST, ALT, LDH, CK, CK-MB levels of both groups were decreased, IL-7 level was increased after treatment, （P〈0.05）; compared with the control group, the AST, ALT, LDH, CK, CK-MB levels of experimental group were lower, the IL-7 level and clinical effective rate were higher（P〈0.05）. Conclusions： Bifid Triple Viable tablets combined Xiao＇er Zhixie＇an granule could reduce the serum myocardial enzyme, isozyme and IL-7 levels of children with acute diarrhea with better clinical efficacy.