前列腺素衍生物类药物降眼压的作用机制

Physiological mechanisms of prostaglandin analogues on lowing intraocular pressure

病理性眼压升高是青光眼主要的危险因素,目前针对青光眼的手术及药物治疗都旨在降低眼压。前列腺素衍生物因具有降眼压作用而成为治疗青光眼的首选药物。现有的研究表明,前列腺素衍生物类药物主要是通过增加房水从葡萄膜巩膜通道外流来降低眼压的,最新的研究发现贝美前列腺素还可以通过增加房水从小梁网通道外流来降低眼压。目前关于前列腺素衍生物类药物降眼压作用机制仍然在不断地了解、观察、研究中。

Pathological elevation of intraocular pressure（IOP）is the most prevalent risk factor in the development and progress of glaucoma. Up to date, all treatments for glaucoma are aimed to lower IOP through surgeries and drugs. Prostaglandin analogues are the first-line IOP-lowing drugs for glaucoma due to their ability to reduce IOP. Enough evidences have suggested that they increase aqueous humor outflow through uveoscleral pathway. More recently, people found that bimatoprost was able to increase aqueous humor outflow through trabecular meshwork-Schlemm＇s canal pathway. Nowadays, a large number of studies are performed to study the mechanism of prostaglandin analogues on lowing intraocular pressure.