果胶铋联合磷酸铝凝胶治疗慢性萎缩性胃炎的疗效观察

Observation of the effect of bismuth pectin combined with aluminium phosphate gel in the treatment of chronic atrophic gastritis

目的 观察果胶铋联合磷酸铝凝胶治疗慢性萎缩性胃炎的临床疗效.方法 选取慢性萎缩性胃炎患者110例,采用数字表法随机分为观察组（n=55）和对照组（n=55）,观察组给予果胶铋联合磷酸铝凝胶治疗,对照组给予果胶铋联合阿莫西林治疗,对比两组患者的临床疗效、病理积分变化及不良反应发生情况.结果 观察组总有效率为87.27％,对照组总有效率为74.55％,两组差异有统计学意义（χ2=5.238,P＜0.05）;观察组萎缩、异型增生、肠上皮化生、慢性炎症、活动性病理积分分别为（2.36±0.79）分、（1.11±0.18）分、（2.19±0.54）分、（1.35±0.27）分、（0.43±0.16）分,显著低于对照组的（1.44±0.57）分、（0.48±0.29）分、（1.38±0.52）分、（0.69±0.22）分、（0.21±0.09）分（t=7.004、13.688、8.013、7.240、8.888,均P＜0.05）;观察组不良反应发生率为5.45％,对照组不良反应发生率为18.18％,观察组不良反应发生率显著低于对照组（χ2=7.777,P＜0.05）.结论 采用果胶铋联合磷酸铝凝胶治疗慢性萎缩性胃炎,能够显著减轻患者的临床症状,临床治疗效果良好,不良反应发生率低,安全可靠,值得在临床上推广使用，

Objective To observe the clinical efficacy of bismuth pectin combined with aluminium phosphate gel in the treatment of chronic atrophic gastritis.Methods 110 patients with chronic atrophic gastritis were randomly divided into observation group（n =55） and control group（n =55）.The observation group received bismuth pectin combined with aluminium phosphate gel treatment,the control group received bismuth pectin and amoxicillin treatment.The occurrence of pathological changes of integral clinical efficacy and adverse reaction were compared between the two groups.Results The total effective rate of the observation group was 87.27%,which was significantly higher than 74.55% of the control group （χ2 =5.238,P 〈 0.05）.The atrophy,intestinal metaplasia,dysplasia,chronic inflammation,activity of pathological scores in the observation group were （2.36 ± 0.79） points,（1.11 ± 0.18） points,（2.19 ± 0.54） points,（1.35 ± 0.27） points,（0.43 ± 0.16） points,respectively,which were significantly lower than （1.44 ± 0.57） points,（0.48 ± 0.29） points,（1.38 ± 0.52） points,（0.69 ± 0.22） points,（0.21 ± 0.09） points in the control group （t =7.004,13.688,8.013,7.240,8.888,all P 〈 0.05）.The incidence rate of adverse reactions of the observation group was 5.45%,which was significantly lower than 18.18% of the control group （χ2 =7.777,P 〈 0.05）.Conclusion Bismuth pectin combined with aluminium phosphate gel in the treatment of chronic atrophic gastritis can significantly reduce the clinical symptoms,and has better clinical curative effect,low incidence of adverse reactions,it is safe,reliable and worthy of promotion in clinical.