不同类型过敏性紫癜患儿血细胞因子水平的变化及意义

Change and Significance of Cytokine Levels in Children with Different Types of Henoch-Schonlein Purpura

目的探讨不同类型过敏性紫癜(HSP)患儿血中IL-6、IL-8、IL-17、IL-23、TNF-α和IFN-γ的变化及意义.方法收集HSP疾病组180例和正常儿童组30例的血标本,疾病组包括HSP患儿腹型初发组的急性期和恢复期各30例,非腹型初发组的急性期与恢复期各30例,腹型复发组急性期30例,非腹型复发组急性期30例.用酶联免疫吸附试验(ELISA)法测定血标本中的IL-6、IL-8、IL-17、IL-23、TNF-α和IFN-γ的水平并进行比较和分析.结果 IL-6、IL-8、IL-17、IL-23、TNF-α疾病组水平均高于正常组,且各型急性期水平高于恢复期水平,复发组水平高于初发组(P<0.05),腹型与非腹型间比较(P>0.05);IFN-γ疾病组水平均低于正常组,且各型急性期水平低于恢复期水平,复发组水平低于初发组(P<0.05),腹型与非腹型间比较异无统计学意义(P>0.05).结论过敏性紫癜患儿血中IL-6、IL-8、IL-17、IL-23、TNF-α和IFN-γ出现明显变化,提示这些因子与过敏性紫癜的发病和转归过程有关.

Objective To study the change of levels of IL-6, IL-17, IL-23, IL-8, TNF-aand IFN-y and their clinical significance on children with different types of Henoch-Schonlein purpura （HSP） Methods The blood specimens of 180 children with HSP as disease group and 30 health children as normal group were collected respectively. Disease group included 30 children at acute stage and 30 at convalescence stage of primary abdominal type, 30 at acute stage and 30 at convalescence stage of primary non-abdominal type, 30 at acute stage of secondary abdominal type, and 30 at acute stage of secondary non-abdominal type. The plasma levels of IL-6, IL-8, IL-17, IL-23, TNF-a and IFN-y in the two groups were measured by ELISA method for comparison and analysis. Results The plasma levels of IL-6, IL-8, IL-17, IL-23 and TNF- cx in disease group were higher than those in the normal group （P〈O.05） . Those levels in the children at acute stage and of primary group were also found to be higher than those at convalescence stage （P〈O.05） and of secondary group （P〈O.05） respectively. Comparison of [L-6, IL-8, IL-17, [L-23 and TNF- abetween abdominal type and the