职业暴露时间对二甲基乙酰胺作业人员肝功能的影响

Influence of occupational exposure time on liver function among workers exposed to dimethylacetamide

目的探讨二甲基乙酰胺职业接触时间的不同对肝损害的程度是否存在差异。方法现场检测确定二甲基乙酰胺浓度,根据职业接触人群在职期间的健康监护数据,用SPSS 20.0软件包,分别计算参检者的肝脏指数,并采用卡方检验和方差分析(ANOVA)进行统计学分析。结果二甲基乙酰胺职业接触会引起肝脏损害。不同性别接害员工肝功能异常率差异有统计学意义(χ2=12.588,P<0.01);不同接害年限工人的肝脏损伤程度存在差异,且差异有统计学意义(F=12.043,P<0.01)。结论二甲基乙酰胺对职业接触人群的肝损害程度在不同接害时间下存在差异,随着接害时长的累积或可产生耐受效应。

[Objective]To investigate the difference in liver damage induced by dimethylacetamide（DMAC）among workers with different occupational exposure time. [Methods]The concentration of DMAC was detected,and the on-service health examination data of occupational exposure workers were collected. The liver indexes of objects were calculated by using SPSS 22.0 software,and the statistical analysis was performed by Chi square test and ANOVA. [Results]The occupational exposure to DMAC could cause liver damage. The difference in incidence rate of abnormal liver function was statistically significant between sex groups（χ2=12.588,P〈0.01）,and there was statistically significant difference in degree of liver damage among workers with different exposure years（F=12.043,P〈0.01）. [Conclusion]There is difference in degree of liver damage induced by DMAC among workers with different exposure time,and tolerance effect may occur with the accumulation of exposure time.