锌对细胞凋亡及纯钛种植体表面骨结合影响研究进展

Research advance of impact of zinc on apoptosis and the osseointegration on the surface of pure titanium implants

锌是机体必需的微量元素,对各种器官和组织的生理调节起着至关重要的作用。锌对细胞凋亡具有重要的生物学影响,可抑制细胞凋亡,亦可诱导细胞凋亡,取决于细胞内锌的浓度。锌影响细胞凋亡的机制比较复杂,是多种因素共同作用的结果。锌对细胞凋亡的影响具有细胞特异性,作用于不同种类细胞,其凋亡通路不尽相同。口腔种植体纯钛表面微弧氧化法加入适宜浓度的锌可促进成骨细胞的增殖分化与骨基质的形成,同样,不同浓度的锌亦可影响成骨细胞的凋亡,这可能由线粒体通路介导。

Zinc is a necessary trace element for organism, which important to the physiological regulation of organs and tissues. Zinc has an important biological effect in the process of apoptosis ; it can inhibit apoptosis and induce apoptosis, both depending on intracellular concentration of zinc. The mechanism of zinc in influencing apoptosis is complex, which is the result of joint action of a variety of factors. Appropriate concentration of zinc coating on the surface of dental implants, which are made of pure titanium, modified by micro-arc oxidation, can promote the proliferation and differentiation of osteoblasts and the formation of bone matrix;also, different concentrations of zinc can affect the apoptosis of osteoblastic cells, probably through a mitochondria-mediated pathway.