甲状腺功能亢进患者血尿酸水平与甲状腺激素水平的相关性分析

Research on the correlation between the levels of thyroid hormone and blood uric acid in patients with hyperthyroidism

目的探讨甲状腺功能亢进(甲亢)患者血尿酸水平与甲状腺激素(TH)水平的相关性。方法选取2016年1月至12月巴彦淖尔市医院门诊及住院的46例甲亢患者为甲亢组,以46例健康体检者为对照组,检测TH与血尿酸的水平,采用Pearon线性相关性检验,分析TH与血尿酸水平的相关性。结果甲亢组治疗前后游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)和血尿酸水平比较差异均有统计学意义[FT3(pmol/L):14.79±8.26比8.96±3.56,FT4(pmol/L):39.31±18.52比21.75±5.92,TSH(m U/L):0.13±0.62比1.99±0.65,血尿酸(μmol/L):334.50±91.12比221.77±55.67,均P<0.05];甲亢组治疗前FT3、FT4、TSH和血尿酸水平与对照组比较差异有统计学意义[FT3(pmol/L):14.79±8.26比4.49±0.82,FT4(pmol/L):39.31±18.52比16.75±2.63,TSH(m U/L):0.13±0.62比3.07±0.79,血尿酸(μmol/L):334.50±91.12比155.97±34.52),均P<0.05]。甲亢患者的血尿酸水平随着TH水平的升高而升高,治疗后FT3、FT4与血尿酸水平呈正相关(FT3:r=0.457,P=0.001;FT4:r=0.322,P=0.029)。结论甲亢患者的血尿酸水平与TH水平密切相关。

Objective To research the correlation between the levels of thyroid hormone and blood uric acid in patients with hyperthyroidism （HT）. Methods 46 patients with hyperthyroidism in outpatient and admitted to the Bayannaoer Municipal Hospital from January 2016 to December 2016 were enrolled in the trial and set as the HT group, while the other forty-six healthy aduhs who did health examination in the same time were enrolled in the trial and set as the control group. The thyroid hormone level and the blood uric acid level were detected. The correlation between the levels of thyroid hormone and blood uric acid was analyzed by pearon linear correlation test. Results The levels of FT3, FT4, TSH and blood uric acid before and after treatment were compared in the HT group, the differences were statistically significant [FT3 （pmol/L）： 14.79±8.26 vs. 8.96 ±3.56, FT4 （pmol/L）： 39.31 ± 18.52 vs. 21.75 ±5.92, TSH （mU/L）： 0.13 ±0.62 vs. 1.99 ±0.65, blood uric acid （μmol/L）： 334.50± 91.12 vs. 155.97 ± 34.52, all P 〈 0.05]. Compared with the control group, the differences of the levels of FT3, FT4 and serum uric acid before treatment in the HT group were statistically significant [FT3 （pmol/L）： 14.79 ±8.26 vs. 4.49 ±0.82, FT4 （pmol/L）： 39.31 ±18.52 vs. 16.75 ±2.63, TSH （mU/L）： 0.13 ±0.62 vs. 3.07±0.79, blood uric acid （μmol/L）： 334.50± 91.12 vs. 155.97± 34.52, all P〈 0.05]. The level of blood uric acid increased with the increase of thyroid hormone levels in patients with hyperthyroidism, and blood uric acid level is positively correlated with FT3 and FT4 level （FT3 r： = 0.457, P = 0.001; FT4 r： = 0.322, P = 0.029 ）. Conclusion The level of the blood uric acid was closely related to the level of thyroid hormone in patients with hyperthyroidism.