脂蛋白相关磷脂酶A2与缺血修饰白蛋白在冠心病诊断中的表达与相关性

Expression and correlation of lipoprotein associated phospholipase A2 and ischemia modified albumin in diagnosis of coronary atherosclerotic heart disease

目的探讨脂蛋白相关磷脂酶A2(LP-PLA2)与缺血修饰白蛋白(IMA)在冠状动脉粥样硬化性心脏病(冠心病)诊断中的表达与相关性。方法选择江门市人民医院2016年4月至9月收治的108例冠心病患者(冠心病组),采集临床资料,检测血清LP-PLA2、IMA,同时检测超敏C反应蛋白(hs-CRP)、超敏心肌肌钙蛋白I(hs-TnI)及肌酸激酶同工酶(CK-MB)。以44例健康体检者为对照(健康对照组);统计分析各项指标在各组的检测均值和相关性。结果冠心病组LP-PLA2、IMA水平均明显高于健康对照组[LP-PLA2(μg/L):309.14±84.89比158.53±32.74,IMA(kU/L):104.11±33.80比67.95±15.89],差异均有统计学意义(均P<0.01)。LP-PLA2和IMA相关(r=0.524,P<0.01),IMA与hs-CRP、hs-cTnI、CK-MB相关(r=0.287、0.215、0.374,均P<0.05)。结论炎症和心肌缺血及心肌损伤存在密切关系;对于冠心病患者,IMA和LP-PLA2是良好的临床预后指标。

Objective To investigate the expression and correlation of lipoprotein associated phospholipase A2 （LP-PLA2） and ischemia modified albumin （IMA） in the diagnosis of coronary atherosclerotic heart disease （coronary heart disease）. Methods 108 cases of patients with coronary heart disease （CHD group） and 44 healthy control subjects （healthy control group） in Jiangmen People＇s Hospital were selected from April to September 2016, the clinical data were collected, the levels of serum LP-PLA2, IMA and high sensitive C reactive protein （hs-CRP） and high-sensitivity cardiac troponin I （hs-TnI）, creatine kinase isoenzyme （CK-MB） were detected, the mean value and correlation of the detection indicators in each group were analyzed statistically. Results The levels of LP-PLA2 and IMA in CHD group were significantly higher than those in healthy control group [LP-PLA2 （μg/L）： 309.14±84.89 vs. 158.53 ± 32.74, IMA （kU/L）： 104.11±33.80 vs. 67.95 ± 15.89], the difference was statistically significant （all P 〈 0.01）. Here was correlation between LP and IMA （r = 0.524, P 〈 0.01）, there was correlation among IMA and hs-CRP, hs-cTnI, CK-MB （r = 0.287, 0.215, 0.374, P 〈 0.05）. Conclusions There was close relationship between inflammation and myocardial ischemia and myocardial injury. For patients with coronary heart disease, IMA and LP-PLA2 were good prognostic indicators.