影响青年颈动脉血栓发生的多因素分析

Multi-Factor Analysis of Influencing Factors of Youth Carotid Artery Thrombosis

目的探讨青年颈动脉血栓患者发生的危险因素,为其临床预防及诊疗提供一定依据.方法随机选择2012年10月至2015年6月在昆明市盘龙区人民医院就诊的23例青年颈动脉血栓患者(实验组),40例无动脉血栓的青年患者(对照组).分别收集2组患者的年龄、性别、体重指数、吸烟、饮酒史、高血压、颈部外伤史,超敏C反应蛋白、总胆固醇、甘油三酯、HDL-C、LDL-C、尿酸、梅毒抗体、HIV抗体,进行相关统计学分析.结果 2组患者基本情况:性别、BMI有统计学差异(P<0.05);2组患者既往病史及个人史:糖尿病、高血压、吸烟、饮酒、颈部外伤史、梅毒抗体均有统计学差异(P<0.05);2组患者生化指标:HDL、尿酸均有统计学差异(P<0.05);多因素分析:高血压(0R=6.43)、吸烟(OR=4.63)、颈部外伤史(OR=3.13)均是危险因素.结论高血压、吸烟、颈部外伤史是青年颈动脉血栓发生的危险因素,以后应加强高血压、吸烟、颈部外伤史防治,从而达到降低青年颈动脉血栓发生率.

Objective To research the risk factors of youth carotid artery thrombosis, to provide some basis for its clinical prevention and treatment. Methods Twenty-three patients of youth carotid artery thrombosis （experimental group）, 40 patients without youth carotid artery thrombosis （control group） were selected, and we collected the data including age, sex, body mass index, smoking, drinking history, hypertension, neck trauma, C reactive protein, total cholesterol, triglyceride, LDL-C, HDL-C, uric acid, syphilis antibody, HIV antibody, then we did statistical analysis. Results The basic situation of the two groups： there were statistical differences in sex and BMI （P 〈0.05） ; past medical history and personal history of patients in two groups： diabetes, high blood pressure, smoking, drinking, history of neck injury, syphilis antibody had statistical differences （P〈0.05） ; biochemical indicators of two groups of patients： there were statistical differences in HDL and uric acid （P〈0.05） ; multi factor analysis： risk factors were hypertension （0R=6.43） , smoking （OR=4. 63） and neck injury history （OR=3.13） . Conclusions The risk factors of youth carotid artery thrombosis are hypertension, smoking, neck injury history, the prevention and cure of hypertension, smoking and neck injury should be strengthened, so as to reduce the incidence of carotid artery thrombosis.