HAART使用的HIV感染者口腔真菌菌群特征

Characteristics of Fungus Colony in Oral Cavity of HIV-infected Patients with Highly Active Antiretroviral Therapy(HAART)

目的初步探明昆明地区使用HAART的HIV患者口腔念珠菌等真菌的分布特点.方法采用黏膜拭子法收集45例用和54例未用HAART的HIV患者口腔标本,进行真菌培养和分离,用梅里埃API 20C AUX酵母菌鉴定试剂盒鉴定菌种,使用SPSS统计软件对结果进行统计分析.结果未用和用HAART组的HIV患者口腔念珠菌检出率分别为53.3%和20.4%,差异有统计学意义(χ2=11.669,P<0.01),说明未用HAART组念珠菌检出率明显高于HAART组,即HAART降低患者口腔念珠菌检出率.在分离到的41株念珠菌,白色念珠菌占78.0%,其次为近平滑和光滑念珠菌各占9.8%,热带念珠菌占2.4%.结论 HAART使用降低了口腔念珠菌检出率,但无症状携带率改变不大.

Objective To identify the characteristics oral fungus in HIV- infected patients with HAART in Kunming. Methods Oral mucosal swab samples were collected from 99 patients with HIV infection with or without HAART. The fungi were isolated and cultured, and were identified by using API 20 C AUX yeast identification system. Results The positive rate of oral Candida in was significantly higher in HIV-infected patients without HAART （53.3%） than those with HAART （20.4%） （ X2=11.669, P〈0.01） . In 41 strains of isolated candida, C. albicans was the most prevalent （78.0%） , followed by C parapsilosis （9.8%） , C.glahrata （9.8%） and C tropicalis （2.4%） . Conclusions HAART can decrease the positive rate of oral Candida in patients with HIV infection, hut has little effect on asymptomatic HIV carrier.