产前感染与胎膜早破相关性分析

Correlation Analysis between Prenatal Infection and Premature Rupture of Membranes

目的探讨产前感染与胎膜早破相关性分析.方法选择2014年7月至2015年7月在澄迈县人民医院分娩的胎膜早破产妇83例作为观察组,并随机选择同期分娩的非胎膜早破正常孕妇80例作为对照组,比较2组孕妇产前生殖道感染情况、新生儿发病情况、孕妇血C反应蛋白(CRP)及白细胞计数水平、孕妇羊水细胞因子水平.结果观察组孕妇产前生殖道感染总发生率为74.70%、对照组孕妇产前生殖道感染总发生率为23.75%,2组比较差异具有统计学意义(P<0.05);观察组新生儿呼吸窘迫综合症、肺炎以及高胆红素血症发生率均显著高于对照组(P<0.05);观察组孕妇血CRP、白细胞计数水平均显著高于对照组(P<0.05);观察组孕妇羊水IL-6、IL-8以及TNF-α水平均显著高于对照组(P<0.05).结论产前生殖道感染与胎膜早破具有密切的关系,感染是导致胎膜早破发生的一个原因,胎膜早破可增加新生儿发病率,产前通过血CRP、羊水IL-6、IL-8以及TNF-α水平的检测能够提前预测胎膜早破的风险,从而采取针对性措施避免胎膜早破,或降低胎膜早破后母儿并发症的发生.

Objective To investigate the correlation between prenatal infection and premature rupture of membranes（PROM）. Me thods Eighty- three cases of PROM in People’s Hospital of Chengmai County from July2014 to July 2015 were selected as observation group, and 80 cases of normal pregnant women were randomly selected as control group.Prenatal genital tract infection, neonatal morbidity, maternal serum C reactive protein（CRP） and white blood cell count level, maternal amniotic fluid cell factor level were compared between two groups. Re s ults The total incidence rate in the control group was 23.75%, and the difference was statistically significant（P〈0.05）. The incidence of respiratory distress syndrome, pneumonia and high serum bilirubin in the observation group was significantly higher than those in the control group（P 〈0.05）. The IL- 6, IL- 8 and TNF- α in the observation group were significantly higher than those in the control group（P〈0.05）. Conclus ion Prenatal reproductive tract infection and PROM are closely related.Infection is a factor causing PROM, which increases the rate of neonatal morbidity. Through prenatal test of blood CRP, amniotic fluid IL- 6, IL- 8, and detection of TNF- levels, the risk of PROM can be predicted in advance so that measures can be taken to avoid PROM and PROM- related maternal and fetal complications can be taken.