超声造影时间强度曲线分析在鉴别乳腺良恶性肿块中的应用

Application of Time-intensity Curve Analysis of Contrast-enhanced Ultrasonography in Differential Diagnosis of Malignant and Benign Breast Masses

目的探讨超声造影时间强度曲线分析对鉴别乳腺肿瘤鉴别诊断的应用价值.方法对2015年1月至20105年9月30例经手术病理证实的单发乳腺肿块,共30个乳腺结节进行了超声造影检查和时间强度曲线分析.结果良性组16例,恶性组14例.对良、恶性组时间强度曲线中的灌注斜率(C),峰值强度(A),消退斜率(K),达峰时间(T)以及曲线下面积(Area)5项参数进行统计学处理,其中良、恶性组的灌注斜率(C)为[(0.24±0.41)vs(0.67±0.39)],差异有统计学意义(P<0.05),余4项参数均无统计学意义.结论超声造影时间强度曲线分析对于乳腺肿瘤良恶性鉴别有一定的鉴别作用.

Objective To evaluate the application value of time-intensity curve analysis of contrastenhanced ultrasonography（CEUS） in differential diagnosis of malignant and benign breast masses. Methods From January 2015 to September 2015, 30 patients with one lesion confirmed by surgical pathology were examined by CEUS. Then time-intensity curve analysis was performed. Results 16 lesions were found in the benign group and 14 lesions were in the malignant group. Five parameters of benign and malignant group were statistically analyzed, including Perfusion slope rate（C）,intensity of peak（A）,Subsidence slope rate（K）, time of peak value（T） and area under the curve（Area）. The perfusion slope rate（C） of benign and malignant group is[（0.24±0.41） vs（0.67±0.39） ]. There was no statistical difference between the two groups in intensity of peak（A）, Subsidence slope rate（K）, time of peak value（T） and area under the curve（Area）,except perfusion slope rate（P〈0.05）. Conclusion Time-intensity curve analysis of CEUS has certain effect on differential diagnosis of malignant and benign breast masses.