人血白蛋白在创伤性骨折患者的应用

Application of Human Blood Albumin in Patients with Traumatic Fracture

目的探讨人血白蛋白在创伤性骨折患者的合理应用.方法回顾性分析86例创伤性骨折后低蛋白血症患者的临床资料,其中闭合骨折患者(43例),开放骨折患者(43例),根据是否使用人血白蛋白分别将闭合骨折患者和开放骨折患者分为治疗组和对照组,分别观察治疗效果.结果闭合骨折患者治疗组和对照组在术口愈合时间、软组织肿胀消退时间、白细胞计数、中性粒细胞百分比、C反应蛋白、术口感染率方面比较差异无统计学意义(P>0.05);但开放骨折患者的治疗在应用人血白蛋白后,与对照组在各观察指标方面比较,差异均具有统计学意义(P<0.05).结论并非所有的创伤性骨折后低蛋白血症患者都适合在第一时间应用人血白蛋白,人血白蛋白对于开放骨折后低蛋白血症患者具有明显的治疗优势,可以促进骨折术后恢复,降低感染率,值得推广应用.

Objective To analyze the application of human blood albumin among patients with traumatic fracture. Methods A retrospective analysis was conducted in 86 patients with hypoalbuminemia after traumatic fracture from December 2013 to May 2014 in our hospital, including 43 patients with closed fractures and 43 patients with open fracture. To observe the curative effect, patients with closed fracture and open fracture were divided into the treatment group and the control group respectively according to the use of human albumin. Results Among the patients with closed fracture in the therapeutic group and the control group,wound healing time,soft tissue swelling fade time,white blood cell count, neutrophil percentage, c-reactive protein and wound infection rates were compared and no significant differences were seen（P〈0.05）. In terms of the treatment of open fractures, the observed indicators showed statistical significance after the application of human blood albumin compared with the control group（P〈0.05）. Conclusion Not all the patients with hypoalbuminemia after traumatic fractures are suitable for the application of human blood albumin at the first place. Advantages are seen among patients with hypoalbuminemia after open fractures when they are applied with human blood albumin. Human blood albumin can promote postoperative recovery of the fractures and reduce the risk of infection,which is worthy of popularization and application.