凝血功能和抗凝治疗对肝脏纤维化影响的研究进展

Impact of coagulation function and anticoagulation therapy on liver fibrosis

肝硬化及其并发症包括食管胃底静脉曲张破裂出血、肝性脑病、腹水,是严重危害人类健康的疾病.预防及治疗早期肝硬化即肝纤维化是治疗的关键.为了攻克此类难题,减轻其带给人类的痛苦,医学专家、学者相继开展了一系列动物及临床研究,旨在寻找一种安全、高效、可靠的药物延缓肝纤维化进程,甚至使肝脏功能逆转.该综述介绍了国内外学者对肝脏纤维化的定义,重点评述凝血功能对肝脏纤维化进程的影响以及中西医抗凝治疗肝脏纤维化的动物实验与临床研究进展,并概述了不同抗凝药物防治肝纤维化的优缺点及治疗不良反应等.

Liver cirrhosis and its complications,including esophageal and gastric variceal bleeding,hepatic encephalopathy,and ascites,can cause serious harm to human health.Therefore,treatment of liver fibrosis is key to the prevention and treatment of liver cirrhosis.In order to treat liver fibrosis to reduce human suffering,medical experts and scholars have performed many clinical and animal studies to find safe,efficient and reliable drugs to slow the progression of hepatic fibrosis and even reverse the liver function.This review introduces the definition of liver fibrosis in China and other countries,discusses the effect of coagulation on the process of liver fibrosis and various anticoagulation therapies for liver fibrosis,and summarizes the advantages,disadvantages,and side effects of different anticoagulants in the prevention and treatment of liver fibrosis.