中枢性性早熟女童血清中维生素D的临床检测意义分析

Clinical significance of serum vitamin D detection in girls with central precocious puberty

目的:探讨中枢性性早熟(CPP)女童血清中维生素D的临床检测意义。方法:选取2013年10月~2015年10月在本院门诊就诊的女童中枢性性早熟(CPP)女童68例为观察组,另选择51例健康女童为对照组。记录并统计所有女童的一般资料;检测血清游离促甲状腺激素(TSH)、促卵泡雌激素峰值(P-FSH)、卵泡刺激素(FSH)、促黄体生成素峰值(P-LH),黄体生产素(LH)水平和血清雌二醇(E2)水平。结果:CPP女童与正常女童相比,血清中25-OHD水平相比差异有统计学意义(P<0.05);维生素D水平缺乏组和维生素D水平正常组的比较中,乳房发育年龄、血清P-FSH、P-LH和E2水平差异有统计学意义(P<0.05)。结论:维生素D缺乏与CPP女童乳房发育年龄密切相关,可能与血清P-FSH、P-LH和E2水平有关。

Objectives：To investigate the clinical significance of serum vitamin D detection in girls with central precocious puberty（CPP）. Methods：68 girls with CPP treated in the hospital from October 2013 to October 2015 were selected as observation group,and another 51 healthy girls was selected as control group. The general information and serum free thyroid stimulating hormone（TSH）,follicle-stimulating estrogen peak（P-FSH）,follicle-stimulating hormone（FSH）,luteinizing hormone peak（P-LH）,corpus luteum production hormone（LH） levels and serum estradiol（E2） levels of all the girls were recorded and analyzed. Results：Difference in serum 25-OHD levels was statistically significant between the two groups（P〈0. 05）. Difference in breast development age,serum pro follicular estrogen peak（P-FSH）,luteinizing hormone peak（P-LH） and estradiol（E2） level was significant between the group lacking vitamin D and the group with normal vitamin D level（P〈0. 05）. Conclusion：Vitamin D deficiency and central precocious puberty（CPP） is closely related to age of breast development,which may be associated with serum follicle stimulating estrogen peak（P-FSH）,luteinizing hormone peak（P-LH） and estradiol（E2） levels.