卡介菌多糖核酸联合伐昔洛韦对生殖器疱疹患者Th1/Th2细胞因子的影响

Effects of BCG-PSN combined with valaciclovir on Th1/Th2 cytokines of patients with genital herpes

目的:探讨卡介菌多糖核酸联合伐昔洛韦对生殖器疱疹患者Th1/Th2细胞因子的影响。方法:72例复发性生殖器疱疹患者,分为对照组和观察组。对照组使用盐酸伐昔洛韦,观察组采用盐酸伐昔洛韦联合卡介菌多糖核酸治疗。结果:治疗后,观察组患者IL-4水平和IFN-γ水平均优于对照组,差异有统计学意义(P<0.01)。治疗后,观察组患者中性粒细胞、Ig G、Ig A、Ig M及C3指标优于对照组,差异有统计学意义(P<0.01)。观察组疗效高于对照组,复发率少于对照组,差异有统计学意义(P<0.05)。结论:盐酸伐昔洛韦联合卡介菌多糖核酸治疗生殖器疱疹疗效显著,纠正Th1/Th2的失衡,改善患者机体免疫功能,降低患者复发率。

Objectives： To explore the effects of BCG Polysaccharide Nucleic Acid （BCG- PSN） Injection combined with Valaciclovir on Th1/Th2 cytokines in patients with genital herpes. Methods： 72 patients with recurrent genital herpes were divided into control group and observation group. Patients in the observation group were given Valacyclovir Hydrochloride combined with BCG - PSN for treatment, whereas those in the control group taken Valaciclovir only. Results ： After treatment, the IL - 4 level and IFN - gamma water of patients in the observation group was better than that of the control group, with statistically significant difference （ P 〈 0.01 ）. After treatment, the neutrophil, IgG, IgA, IgM and C3 index of patients in the observation group was better than that of the control group, with statistically significant difference （P 〈0. 01 ）. The efficiency was higher and the recurrence rate was lower in the observation group than these of the control group, with statistically significant difference （ P 〈 0. 05 ）. Conclusion ： Valacyclovir hydrochloride combined with BCG - PSN can significantly increase the level of IFN - T, reduce IL -4 level, thus balancing Thl/Th2, which is helpful for the improvement of patients＂ immune function.