创伤骨折患者围术期凝血、纤溶指标的临床观察

Clinical observation of blood coagulation and fibrinolysis in patients with traumatic fracture

目的探讨创伤骨折患者围术期凝血、纤溶指标的变化。方法选取创伤骨折择期手术患者80例作为观察组对象,纳入同期体检的健康志愿者60例作为对照组对象,分别检测部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-D)、凝血酶抗凝血酶复合物(TAT)以及凝血酶原片段(F1+2)。结果术前观察组与对照组相比,APTT与PT差异均无统计学意义(P>0.05);观察组的FIB、D-D、TAT以及F1+2较对照组明显升高,差异均有统计学意义(P<0.05)。观察组围术期APTT、PT差异均无统计学意义(P>0.05);与术前比较,术后24 h、3 d的FIB、D-D、TAT以及F1+2均显著升高,差异均有统计学意义(P<0.05)。结论创伤性骨折患者围术期存在凝血、纤溶指标异常,特别是FIB、D-D、TAT以及F1+2显著升高。

Objective To investigate the changes of blood coagulation and fibrinolysis indexes in patients with traumatic fracture.Methods 80 cases of traumatic fracture were selected as the observation group,and 60 healthy persons were selected as the control group in the same period.We respectively measured APTT,PT,FIB,D-D,TAT and F1 ＋ 2.Results Before surgery,the differences of APTT and PT between observation group and control group had no statistical significance（P〉0.05）;compared with the control group,FIB,D-D,TAT and F1 ＋ 2 in the observation group were significantly higher,and the differences were statistically significant（P〈0.05）.During perioperative period,there was no statistical significance on the differences of APTT and PT in the observation group（P〉0.05）; compared with before surgery,FIB,D-D,TAT and F1 ＋ 2significantly increased at 24 hours and 3 days after surgery,and the differences were statistically significant（P〈0.05）.Conclusion There was abnormal changes of blood coagulation and fibrinolysis indexes in patients with traumatic fracture,especially FIB,D-D,TAT and F1 ＋ 2 significantly increased.