血清B型脑钠肽水平对慢性心力衰竭诊治价值及其与心功能分级的相关性研究

Study on the diagnostic and treatment value of serum B-type natriuretic peptide levels for the chronic heart failure and its correlation with cardiac function classification

目的 探讨血清B型脑钠肽（BNP）水平对慢性心力衰竭的诊治价值,并分析其与心功能分级的相关性.方法 选择慢性心力衰竭住院患者155例作为治疗组,心功能分级,Ⅱ级48例,Ⅲ级56例,Ⅳ级51例.选取同期门诊健康者122例作为对照组.检测两组研究对象血清BNP水平,分析治疗组患者治疗前后BNP水平及其与心功能的相关性.结果 治疗组血清BNP为（738.67±61.32） pg/mL,高于对照组的（22.36 ±21.89） pg/mL,差异有统计学意义（t=19.38,P 〈0.05）.治疗组治疗后血清BNP为（329.58±90.74） pg/mL,低于对照组的（738.67±161.32） pg/mL,差异有统计学意义（t=19.38,P〈0.05）;Ⅱ级、Ⅲ级、Ⅳ级患者治疗后与治疗前血清BNP差异均有统计学意义（t=13.65、15.18、17.39,均P〈0.05）,治疗前和治疗后BNP均随着分级的增加逐渐增高,差异均有统计学意义（=10.61、21.33、11.06、16.40,均P〈0.05）.结论 慢性心力衰竭患者血清BNP水平显著升高,并随着心功能分级的增加而上升,呈相关性,作为慢性心力衰竭的客观指标,具有较好的临床诊治价值,并对预后评估具有重要意义.

Objective To explore the diagnostic and treatment value of serum B-type natriuretic peptide （BNP） levels for the chronic heart failure and its correlation with cardiac function classification.Methods 155 patients with heart failure were selected as treatment group.According to cardiac function,grade Ⅱ in 48 cases,grade Ⅲ in 56 cases,grade Ⅳ in 51 cases.122 healthy people during the same period were selected as the control group.Retrospectively detected serum BNP levels of the subjects,and the BNP levels of the treatment group were detected before and after treatment,and its correlation with heart function was analyzed.Results The serum BNP level of the treatmentgroup was （738.67 ± 61.32） pg/mL,which was higher than （22.36 ± 21.89） pg/mL of the control group,the difference was statistically significant （t =19.38,P 〈 0.05）.The serum BNP level of the treatment group after treatment was （329.58 ± 90.74） pg/mL,which was lower than （738.67 ± 161.32） pg/mL of the control group,the difference was statistically significant（t =19.38,P 〈 0.05）.The serum BNP levels of grade Ⅱ,grade Ⅲ and grade Ⅳ patients after treatment compared with pre-treatment,the differences were statistically significant （t =13.65,15.18,17.39,all P 〈 0.05）,from pre-treatment to pro-treatment,the serum BNP levels were gradually increased with increased grade,the differences were statistically significant （t =10.61,21.33,11.06,16.40,all P 〈 0.05）.Conclusion The serun BNP level of chronic heart failure patients significantly increases,and it increases with the increase of cardiac function classification,and shows correlation.As the objective indicators of chronic heart failure,it has better clinical diagnosis value and treatment and prognostic significance.