血必净注射液辅助治疗重症肺部感染的疗效观察

Observation of clinical effect of Xuebijing injection adjuvant therapy for severe lung infection

目的 探讨血必净注射液联合抗生素对ICU重症肺部感染的临床疗效及作用机制.方法 110例ICU重症肺部感染患者按数字表法随机分为对照组（55例）和观察组（55例）,对照组给予头孢噻肟钠和苯唑青霉素钠治疗,观察组给予血必净注射液联合头孢噻肟钠、苯唑青霉素钠治疗,共治疗7d,同时检测治疗前后患者血清C-反应蛋白、TNF-α、IL-6、环加氧酶-2和超氧岐化酶水平.结果 治疗后,两组的血清CRP和TNF-α、IL-6水平显著降低[治疗后对照组CRP、TNF-α、IL-6值分别为：（46.50±17.74） ng/L,（339.50±112.61） ng/L,（141.20±42.66）ng/L;观察组CRP、TNF-α、IL-6值分别为：（35.60±16.89） ng/L,（268.20±98.47） ng/L,（118.70±39.81） ng/L;对照组t值分别为7.329、9.682、6.038;观察组t值分别为11.012、14.335、14.335;P值均小于0.01],且观察组降低幅度均显著大于对照组（t=3.300,P〈0.01）.同时两组患者血清COX-2和SOD水平均显著降低[治疗后对照组COX-2和SOD值分别为：（189.50±34.52） ng/L,（203.60±67.26） U/mL;观察组COX-2和SOD值分别为：（118.20±25.36） ng/L,（162.30 ±59.78） U/mL;COX-2：对照组,t=15.021,P〈O.01;观察组,t=32.931,P〈0.01;SOD：对照组,t=4.183,P〈0.01;观察组,t=7.682,P〈0.01）,且观察组降低幅度更显著（t=3.404,P〈0.01）.结论 血必净注射液联合抗生素治疗ICU重症肺部感染效果优于抗生素单用,其主要机制是抑制环加氧酶-2和超氧岐化酶活性来改善炎性反应和氧化应激损伤.

Objective To study the clinical effects and mechanism of Xuebijing injection combined with antibiotics in the treatment of severe lung infection in ICU.Methods 110 cases of ICU severe lung infection were randomly divided into control group（55 cases） and observation group（55 cases）.The control group was administered with cefotaxime sodium and sodium benzene azole penicillin,while the observation group was co-administered with Xuebijing injection and cefotaxime sodium,sodium benzene azole penicillin.All treatment lasted for 7 days.Meanwhile,the serum levels of C-reactive protein （CRP）,TNF-α,IL-6,COX-2 and SOD were measured before and after the therapy.Results After treatment,the levels of CRP and TNF-α,IL-6 were significantly reduced in the two groups[after treatment CRP,TNF-α,IL-6 levels of the control group：（46.50 ± 17.74） ng/L,（339.50 ± 112.61） ng/L,（141.20 ± 42.66） ng/L;and those in the observation group：（35.60 ± 16.89） ng/L,（268.20 ± 98.47） ng/L,（118.70 ± 39.81） ng/L;the control group：t =7.329,9.682,6.038;the observation group：t =11.012,14.335,14.335,all P 〈 0.01],and the reduced amplitude of the observation group was significantly lower than that of the control group （t =3.300,P 〈 0.01）.The serum levels of COX-2 and SOD were significantly reduced [after treatment COX-2 and SOD levels of the control group：（189.50 ± 34.52） ng/L,（203.60 ± 67.26） U/mL;those of the observation group：（118.20 ± 25.36） ng/L,（162.30 ± 59.78） U/mL;COX-2：the control group：t =15.021,P 〈 0.01;the observation group：t =32.931,P 〈 0.01;SOD：the control group,t =4.183,P 〈 0.01;the observation group,t =7.682,P 〈0.01],and the reduced amplitude of the observation group was significantly lower than that of the control group（t =3.404,P 〈0.01）.Conclusion Xuebijing injection combined with antibiotics in the treatment of severe lung infection in ICU has good effects,which is due to the inhibition of COX-2 and SOD to improve inflammation and oxidative stress damage in cells.