MEBO治疗传统疗法难于收效创面的临床报告

Clinical Study of MEBO in the Treatment of Refractory Wounds Associated with Conventional Management

目的 :观察湿润烧伤膏 (MEBO)治疗传统疗法难于收效创面的疗效。方法 :将 1990— 2 0 0 1年临床治疗的残余创面、植皮创面、骨裸露创面及中途改换MEBO治疗焦痂创面的临床疗效进行对比治疗观察。结果 :残余创面治疗组 2 0天治愈率与治愈天数分别为 10 0 %和 8 6± 3 6天 ,对照组为 6 5 %和 14 5± 4 8天 ,组间相比无为P <0 0 1;植皮创面治疗组昼夜愈合速度与痊愈天数分别为 5 6 1± 1 19%和 15 6 4± 2 2 7天 ,对照组为 3 86± 1 2 1%和19 85± 4 4 7天 ,组间相比均为P <0 0 1;骨裸露创面早期实行MEBO治疗痊愈天数为 4 8 6 1± 7 4 7天 ,后期改用MEBO治疗者骨膜与骨皮质广泛坏死 ,愈合天数明显延长 ;伤后 4周改用MEBO治疗的焦痂创面仍能产生新生“皮丁”或“皮岛”组织 ,最终实现再生愈合。结论 :MEBO能为多种类型创面提供生理性湿润环境和有效地治疗传统疗法难于收效创面的病象 。

Objective: To investigate the therapeutic effects of MEBO in the treatment of refractory wound associated with conventional management. Method: A comparative study was conducted. The therapeutic effects of MEBO in the treatment of residual burn wounds, skin grafted wounds, bone exposed wounds and eschar-formed wounds (full thickness) in the middle stage of treatment course were observed during 1990 to 2001, all these wounds were treated with conventional method in the early stage of the treatment. Results: The mean 20 day healing rate was 100% and the healing time of residual burn wounds was 8.6±3.6 days, compared with 65% and 14.5±4.8 days in the control group treated with conventional method, (P<0.01). In skin grafted wounds, mean healing rate and healing time were 5.61±1.19% and 15.64±2.27 days respectively in the wounds treated with MEBO, compared with 3.86±1.21% and 19.85±4.47 days in the wounds treated with conventional method (P<0.01). The healing time for bone-exposed wounds treated with MEBO at the early stage was 48.61±7.47 days, compared with the long healing of those treated with MEBO at the later stage due to extensive necrosis of periosteum and the bone cortex. The 'skin patch' or 'skin island' also may be present on previous eschar-formed wounds treated with MEBO at 4 weeks post injury, leading to regenerative healing ultimately. Conclusion: MEBO provides a physiological most environment for wounds caused by various incidents and effectively treats refractory wounds associated with conventional management. Stem cells might be involved in the healing process of various wounds.