柴胡疏肝散联合西药治疗胆汁反流性胃炎随机平行对照研究

CHSGS Combined with Western Medicine in the Treatment of Bile Reflux Gastritis Randomized Controlled Study

[目的]观察柴胡疏肝散联合西药治疗胆汁反流性胃炎疗效。[方法]使用随机平行对照方法,将114例门诊患者按就诊顺序号方法随机分为两组。对照组57例多潘立酮,3次/d,10mg/次,饭前30min服用;奥美拉唑,1次/d,40mg/次;阿莫西林,3次/d,0.5g/次。治疗组57例柴胡疏肝散(白芍15g,枳壳12g,柴胡9g,陈皮、川芎、香附、炙甘草各6g;明显疼痛加延胡索12g,川楝子9g;严重呕吐加半夏6g;胃脘灼热、发苦,烦躁易怒加丹皮、栀子各9g,蒲公英20g;频繁嗳气加沉香6g,旋覆花5g;反酸明显加乌贼骨15g,煅瓦楞子12g;腹胀突出加厚朴10g,大腹皮12g;便秘加大黄6g;气虚加黄芪、党参各30g);1剂/d,水煎200mL,早晚口服;西药治疗同对照组。连续治疗15d为1疗程。观测临床症状、症状评分(上腹疼痛、腹胀、恶心、呕吐胆汁)、不良反应发生率。治疗1疗程,判定疗效。[结果]治疗组痊愈19例,显效21例,有效16例,无效1例,总有效率98.25%;对照组痊愈16例,显效18例,有效13例,无效10例,总有效率82.46%;治疗组疗效优于对照组(P<0.05)。上腹疼痛、腹胀、恶心、呕吐胆汁评分改善治疗组优于对照组(P<0.01)。不良反应发生率两组间无明显差异(P>0.05)。[结论]柴胡疏肝散联合西药治疗胆汁反流性胃炎,疗效满意,无严重不良反应,值得推广。

[Objective] To observe the CHSGS combined with western medicine in treating bile reflux gastritis. [Method] Using random parallel control method, 114 patients were randomly divided into two groups randomly, the control group of 57 cases domperidone, 3/d, 10mg/, 30rain before taking omeprazole, 1; / d, 40rag/; amoxicillin, 3 times/d, 0.5 g/times. The treatment group of 57 eases CHSGS （15g 12g of Fructus anrantii, Radix Paeoniae Alba, Radix 9g, tangerine peel, Rhizoma Chuanxiong, Rhizoma Cyperi, licorice root each 6G; obvious pain add Corydalis 12g, Kawa Ko 9g; severe vomiting with Pinellia 6g; epigastrie burning, bitter, irritability and paeonol, gardenia 9g, dandelion 20g; frequent belching and incense 6g, Inula 5g; acid significantly cuttlefish bone 15g, calcined concha Arcae 12g; abdominal distension prominent Houpu log, dafupi 12g; constipation and rhubarb 6g; Qi Astragalus, Codonopsis, 30g）; 1 agent/d, 200mL oral decoction, sooner or later; westernmedicinewiththecontrolgroup. Continuous treatment with 15d for 1 courses. Observation of clinical symptoms symptoms, evaluation Points （abdominal pain, abdominal distension, nausea, vomiting bile）, the incidence of adverse reactions. To judge the curative effect of treatment of 1 treatment. [Results] The treatment group 19 cases were cured, 21 cases markedly effective, 16 cases effective, 1 cases ineffective, the total efficiency of 98.25%; control group 16 cases were cured, 18 cases markedly effective, 13 cases effective, 10 cases ineffective, the total efficiency of 82.46%; the treatment group than the control group （P〈0.05）. The upper abdominal pain. Abdominal distension, nausea, vomiting and bile were improved in treatment group than in control group （P〈0.01）. The incidence of adverse reactions between the twogroups had no significant difference （P〉0.05）. [Conclusion] CHSGS combined with western medicine in the treatment of bile reflux gastritis, satisfactory curative effect, no serious adverse reactions, worthy of promotion.