无灶性癫痫静息态功能MRI默认模式网络特点研究

DEFAULT MODE NETWORK STUDY OF THE RESTING-STATE FUNCTIONAL MAGNETIC RESONANCE IMAGING IN NONLESIONAL EPILEPSY

目的探讨无灶性癫痫病人静息态功能MRI默认模式网络的特点。方法收集20例无灶性癫痫病人和22例正常志愿者的临床资料及静息态功能MRI数据,采用功能连接分析方法观察两组被试默认模式网络,并进行对照分析。结果无灶性癫痫组与正常对照组相比,默认模式网络功能连接增强的脑区有右额中回、右中央前回、左额中回、右中央后回、右颞中回、左颞中回、左缘上回及左小脑扁桃体;功能连接减弱的脑区有右额上回、右角回、右楔前叶及右前扣带回。结论无灶性癫痫病人静息状态下默认模式网络功能连接发生异常,原因可能为长期的异常放电导致颞叶、额叶、顶叶、楔前叶以及边缘叶等广泛的脑区损害。

Objective To explore the default mode network（DMN）of nonlesional epilepsy（NLE）patients using resting state functional MRI（rs-fMRI）. Methods Clinical and rs-fMRI data of 20 patients with NLE and 22 normal volunteers were collected.Applying functional connectivity analysis,the DMN of two groups was observed and analyzed. Results Compared with normal control group,in NLE patients,the increased areas of brain region were in the right and left middle frontal gyrus,right and precentral gyrus,right postcentral gyrus,right and left middle temporal gyrus,left supramarginal gyrus and left tonsil of cerebellum.The weakened areas were in the right superior frontal gyrus,right angular gyrus,right precuneus and right anterior cingutate. Conclusion Under the resting state,default mode network function connection in nonlesional epilepsy patients exception occurs,the reasons might due to extensive brain damage-temporal lobe,frontal lobe,parietal lobe,precuneus and limbic lobe-caused by long-term abnormal discharge.