苦参素联合抗组胺药治疗慢性荨麻疹疗效的Meta分析

Meta-analysis of the efficacy of the oxymatrine combined with antihistamines in the treatment of chronic urticaria

目的:评价苦参素联合抗组胺药治疗慢性荨麻疹的疗效及不良反应。方法:检索中国知网、万方、维普、Pubmed、EMbase及Cochrane library等数据库,筛选符合标准的文献,采用RevM an 4.2进行Meta分析。结果:共纳入14篇文献,入选文献发表偏倚较小,无明显异质性(P=0.34)。Meta分析结果显示,苦参素联合抗组胺药组与单用抗组胺药组比较,有效率高[P<0.00001,RR=1.40,95%CI(1.30~1.51)],复发率低[P<0.00001,RR=0.19,95%CI(0.10-0.37)]。结论:苦参素联合抗组胺药治疗慢性荨麻疹疗效优于单用抗组胺药。

Objective：To assess the efficacy of the oxymatrine combined with antihistamines in the treatment of chronic urticaria.Methods：The articles about the oxymatrine combined with antihistamines for treating chronic urticaria were searched in CNKI, WANGFANG database, VIP database, Pubmed, EMbase and Cochrane library.The Meta-analysis was performed by Review Manager 4.2 software.Results：A total of 14 researches were included, with small bias and no heterogeneous （P=0.25）.The results of meta-analyses showed that compared with the group of antihistamines alone, the effective rate in the group of oxymatrine combined with antihistamines was higher （P〈0.00001,RR=1.40, 95% CI（1.30-1.51）） and the recurrence rate was lower （P〈0.00001, RR=0.19,95% CI（0.10-0.37））.Conclusion：Oxymatrine combined with antihistamines was more effective than antihistamines alone in the treatment of chronic urticaria.