针灸联合神经节苷脂及甲钴胺治疗特发性面神经麻痹的疗效观察

Acupuncture combined with ganglioside and mecobalamine injections can relieve the symptoms of idiopathic facial palsy

目的观察针灸联合神经节苷脂及甲钻胺治疗特发性面神经麻痹（IFP）患者的临床疗效。方法将120例IFP患者随机分为神经节苷脂组、甲钴胺组和联合组，每组40例。3组患者均采用常规治疗及针灸治疗，神经节苷脂组在此基础上加用神经节苷脂注射液，甲钴胺组在常规及针灸治疗基础上辅以甲钴胺注射液治疗，联合组采用神经节苷脂及甲钴胺进行治疗，每日1次，共治疗14d。观察治疗前、后的House-Brackmann面神经功能量化评分、患侧面神经复合肌肉动作电位（CMAP）波幅及R1潜伏期。结果联合组治疗后总有效率为95．0％，高于神经节苷脂组（90．0％）及甲钴胺组（87．5％），差异有统计学意义（P〈0．05）。治疗后，联合组患侧CMAP波幅较神经节苷脂组及甲钴胺组有所改善，治疗后联合组R1潜伏期较神经节苷脂组及甲钴胺组缩短，差异均有统计学意义（P〈0．05）。结论针灸联合神经节苷脂钠及甲钴胺注射液治疗IFP的疗效较好，可有效改善IFP患者的临床症状、患侧CMAP波幅及R1潜伏期。

Objective To observe the clinical effect of acupuncture combined with ganglioside and mecobalamine injections on idiopathic facial palsy （IFP）. Methods A total of 120 IFP patients were divided into a ganglioside group, a mecobalamine group and a consociationgronp, each of 40. All were given routine drug and acupuncture treatment, while the ganglioside and mecoblamine groups were additionally provided with the corresponding injections of ganglioside and mecobalamine, respectively. The treatment was administered once daily for a total of 14 days. All the groups were evaluated using the House-Brackmann facial nerve grading system before and after the interventions of 14 days ended. The compound muscle action potential （CMAP） wave amplitude and RI incubation, the motor nerve conduction velocity （MCV） and the sensory nerve conduction velocity （SCV） of the affected facial nerves were observed and compared before and after the 14 days of treatment. Results The total effectiveness rate of the consociation group （ 95.0% ） was significantly higher than that of the ganglioside （ 90.0% ） or the mecobalamine group （ 87.5% ）. After the treatment the CMAP wave amplitude had improved significantly and the R1 latency had shortened significantly in the consociation group compared to the other 2 groups. The average MCV and SCV of the consociation group had also improved significantly compared with the other two groups. Conclusion Acupuncture combined with ganglioside and mecobalamine injections is an effective therapy for idiopathic facial palsy. It can improve the patient＇s clinical symptoms, shorten the CMAP wave amplitude and R1 latency on the affected side and improve MCV and SCV.