帕金森病患者相关生化水平的临床研究

Clinical study on biochemical levels in patients with Parkinson s disease

目的:探讨帕金森病患者相关生化水平与疾病等级、病程的关系。方法:测定69例确诊为帕金森病患者(PD组)以及69例性别、年龄相匹配的健康成人(对照组)的尿酸和血脂水平,并进行统计学分析。结果:PD组血尿酸、三酰甘油、总胆固醇、低密度脂蛋白(LDL-C)水平分别为(322.48±66.18)μmol/L、(1.22±0.86)mmol/L、(4.70±0.92)mmol/L、(3.00±0.85)mmol/L,而对照组分别为(384.23±88.28)μmol/L、(1.64±0.94)mmol/L、(5.37±1.31)mmol/L、(3.53±1.03)mmol/L,两组分别比较,差异均具有统计学意义(t=-4.68,P=0.000;t=-2.74,P=0.007;t=-2.74,P=0.007;t=-3.49,P=0.001;t=-3.27,P=0.001)。PD组中病程>3年者的血尿酸LDL-C水平显著低于病程≤3年者(t=3.373,P=0.001;t=2.440,P=0.017)。Hoehn-Yahr分期中,各期PD患者血尿酸水平均低于对照组(P<0.05);早、中期PD患者各类血脂水平均明显低于对照组(P<0.05);女性PD患者血尿酸、总胆固醇、高密度脂蛋白(HDL-C)分别为(305.69±54.25)μmol/L、(4.99±0.95)mmol/L、(1.25±0.27)mmol/L,男性PD患者为(339.76±73.40)μmol/L,(4.41±0.81)mmol/L、(1.06±0.19)mmol/L,男、女患者间分别进行比较,差异均具有统计学意义(t=2.198,P=0.031;t=-2.721,P=0.008;t=-3.266,P=0.002)。Logistic回归示低血尿酸水平是PD发病的危险因素(OR=1.01,95%CI 1.004~1.015,P=0.001)。结论:PD患者生化水平存在多种改变,尿酸降低可能是帕金森病的危险因素之一。

Objective To analyze the relationship between biochemical level and severity levels and clinical, duration of disease in patients with Parkinson Disease （PD）. Methods 69 patients with PD and 69 healthy persons of similar sex and age were selected in the research. Serum uric acid and lipids levels were examined and compared. Results The serum uric acid, triglyeerides, total cholesterol and low-density lipoprotein cholesterol （LDL- C） were （322.48 ±66.18）μmol/L, （1.22 ± 0.86） mmol/L, （4.70 ± 0.92） mmol/L and （3.00 ± 0.85） mmol/L in control group, and （384.23 ±88.28） μmol/L、（1.64 ± 0.94） mmol/L,（5.37 ± 1.31） mmol/L、 （3.53 ±1.03） mmol/L in control group. The differences are significant （t = -4.68,P = 0.000; t = -2.74,P = 0.007; t = -2.74,P = 0.007; t = -3.49, P = 0.001 ;t = -3.27, P = 0.001）. Serum UA coneentration and high-density lipoprotein cholesterol （HDL-C）, LDL-C were lower in patients with Parkinson＇s disease in duration of disease more than 3 years than those in duration of disease less than 3 years （t = 3.373, P = 0.001; t = 2.440, P =0.017）. The serum UA levels of any stages of PD patients were lower than the control group （P 〈 0.05） according to Hoehn-Yahr staging. All lipid levels in early and middle stage PD disease patients were lower than those in control group （P 〈 0.05）. Serum UA, total cholesterol and HDL-C in female PD patients were （305.69 ± 54.25） μmol/L, （4.99 ± 0.95） mmol/L, （1.25 ± 0.27） mmol/L, and （339.76 ± 73.40） μmol/L, （4.41 ± 0.81） mmol/L, （1.06 ±0.19） mmol/L in male patients. The difference is significant （t = 2.198, P = 0.031; t =-2.721, P = 0.008; t =-3.266, P = 0.002）. Multivariate logistic regression models assessed lower uric acid concentrations is the risk of pD （OR = 1.01, 95%CI 1.004 - 1.015, P = 0.001）. Conclusion Biochemical level changed differently in Parkinson disease and uric acid reduction could be a risk factor for PD.