血清髓鞘碱性蛋白、S100B及血气分析在早产儿脑损伤早期诊断中的价值

Clinical value of serum myelin basic protein, S100B and blood gas analysis in early diagnosis of brain injury in premature infants

目的:探讨血清髓鞘碱性蛋白(MBP)、S100B及血气分析在早产儿脑损伤早期诊断中的意义。方法:选择于我院住院治疗的95例早产儿作为研究对象,其中符合早产儿脑损伤诊断标准的病例45例作为实验组,无脑损伤的早产儿50例为对照组,所有病例分别在出生后第1天和第7天取动脉血查血气分析,并留取静脉血检测MBD和S100B。结果:实验组血气分析p H、PCO2、乳酸值、BE值和S100B蛋白、MBP的水平第7天与第1天存在明显差异,比较结果显示差异均有统计学意义,第1天分别比较各指标,实验组均高于对照组,比较结果差异均有统计学意义。结论:生后第1天检测动脉血气分析、S100B蛋白和MBP水平能够帮助早期诊断早产儿脑损伤。

Objective To investigate the role of mylin basic protein, S100B and arterial blood gas analysis＇s levels in early diagnosis of brain injury in premature infant. Methods A total of 95 premature infants treated in our hospital were enrolled in the study. Experimental group was 45 premature infants with brain injury. Control group was 50 premature infants without brain injury were the. All patients were detected with arterial blood gas analysis, MBP and S100B on the 1st day and 7th day after birth. Results The pH, PCO2, BE, lactic acid, MBP and S100B＇s levels in experimental group were significantly different between the 1st day and 7th day after birth. In the 1st day after birth, compared with the control group, the pH, PCO2, BE, lactic acid, MBP and SIOOB in the experimental group were obviously high than that of control group. Conclusion On the 1st day after birth, monitoring arterial blood gas analysis, S100B protein and MBP＇s levels could be useful in early diagnosis of brain injury in preterm infants.