盐酸甲氧氯普胺注射液预防ST段抬高型心肌梗死急诊PCI术中及术后呕吐的疗效

Preventive effect of metoclopramide dihydrochloride injection on intra-and post-PCI omitting in patients with ST segment elevation myocardial infarction

目的:观察应用盐酸甲氧氯普胺注射液预防ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)术中及术后呕吐的疗效。方法:选择2014年1月至2016年4月进入我院的急诊STEMI,并需要进行PCI治疗的患者132例,随机分为观察组和对照组。观察组患者PCI术前即给予盐酸甲氧氯普胺注射液做呕吐的预防治疗;对照组不给予预防治疗,如出现症状再给予相应的对症治疗。观察术中及术后24 h内呕吐的例数、频次、持续时间及其严重程度。结果:观察组术中和术后24 h内发生呕吐的患者数、呕吐的发生率及呕吐持续的时间均显著的低于对照组,观察组术后24 h内的呕吐严重程度评分显著的低于对照组,差异均具有统计学意义,P<0.05。结论:SEMI急诊PCI术前预防性应用盐酸甲氧氯普胺注射液,可显著的减少患者术中及术后呕吐的发生。

Objective To observe the efficacy of Metoclopramide Dihydrochloride Injection in the prevention of intra- and postoperative vomiting after emergency percutaneous coronary intervention （PCI） in patients with ST segment elevation myocardial infarction. Methods A total of 132 patients with ST segment elevation myocardial infarction and required treatment with PCI were selected from January 2014 to April 2016 and randomly divided into observation group and control group. The patients in observation group were treated with Metoclopramide Dihydrochloride Injection before PCI for preventive treatment, while those in control group were not, only if vomiting occurred, then corresponding symptomatic treatment was provided. The number of patients vomiting, frequency, duration and severity of vomiting during operation and within 24 h after operation were observed. Results The number of patients vomiting, the incidence rate of vomiting and vomiting duration during operation and within 24 h after operation in observation group were significantly lower than those in control group and the score of vomiting severity within 24 h after operation in observation group was significantly lower than that in control group, which indicated statistical differences （P 〈 0.05）. Conclusion Metoclopramide Dihydrochloride Injection is effective for significantly reducing the incidence of intra- and postoperative vomiting after emergency percutaneous coronary intervention （PCI） in patients with ST segment elevation myocardial infarction.