2型糖尿病合并原发性高血压晨峰现象的影响因素

The influencing factors of morning blood pressure surge in type 2 diabetes mellitus patients with essential hypertension

目的:研究合并有2型糖尿病的原发性高血压患者出现血压晨峰现象的相关影响因素。方法:随机选取武汉科技大学附属天佑医院2015-01-2016-06的111例符合条件的患者,根据24h动态血压(ABPM)结果,将患者分为血压晨峰组(MBPS组)38例,及非血压晨峰组(NMBPS组)73例;检测患者的血脂(TC、TG、LDL-C、HDL-C)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、颈动脉内膜-中层厚度(IMT)。对比分析两组患者以上相关数据。结果:两组患者在性别、吸烟、饮酒、年龄、高血压病程、糖尿病病程、TC、TG、LDL-C、HDL-C、FBG等方面的差异无统计学意义(P>0.05);与NMBPS组相比较,MBPS组在BMI、HbA1c、IMT等方面数值升高,差异有统计学意义(P=0.011、0.042、0.001);Pearson相关分析显示BMI、IMT与MBPS呈正相关;多元线性回归分析显示BMI、IMT为血压晨峰现象的影响因素。结论:BMI及IMT是2型糖尿病合并原发性高血压患者血压晨峰现象的重要影响因素。

Objective：To study the influence factors of morning blood pressure surge in type 2diabetes mellitus patients with essential hypertension.Method：The 111 cases of eligible patients from January 2015 to June 2016 were randomly selected.According to the results of ambulatory blood pressure monitoring（ABPM）,patients were divided into 38 cases of morning blood pressure surge group（MBPS）and 73 cases of non morning blood pressure surge group（NMBPS）.We collected the blood lipids（TC,TG,LDL-C,HDL-C）,fasting blood glucose（FBG）,glycosylated hemoglobin（HbA1c）and carotid artery intima-middle thickness（IMT）in these patients.Result：There was no significant difference in gender,smoking,alcohol consumption,age,duration of hypertension,duration of diabetes,TC,TG,HDL-C,FBG,LDL-C,and so on in the two groups（P〉0.05）.Compared with the NMBPS group,the data of BMI,HbA1 c,IMT increased in MBPS group,and the difference was statistically significant.（P=0.011,0.042,0.001）.Pearson correlation analysis showed that BMI and IMT were positively correlated with MBPS.Multivariate linear regression analysis showed that BMI and IMT were the influencing factors of MBPS.Conclusion：BMI and IMT are important influencing factors of morning blood pressure surge in type 2diabetes mellitus patients with essential hypertension.