食管胃肠道间质瘤治疗进展

Recent Progress in Treatment of Esophageal Gastroiontestinal Stromal Tumors

食管胃肠道间质瘤生物学行为较胃肠道间质瘤差,以手术治疗为主,包括内镜下治疗、肿瘤摘除术以及食管部分切除术等。内镜下治疗包括内镜黏膜下剥离术(ESD)、内镜黏膜下隧道肿瘤切除术(STER)。随着微创技术的不断发展和成熟,本着创伤最小、疗效最大的原则,对食管胃肠道间质瘤的手术治疗方式值得进一步深入探讨。近年来,包括新辅助治疗和术后辅助治疗的分子靶向治疗成为胃肠道间质瘤治疗的一大进步,分子靶向治疗的成功开创了肿瘤分子靶向治疗的一个新时代。

The biological behavior of esophageal gastroiontestinal stromal tumors is worse than that of gastrointestinal stromal tumors（GIST）, so surgical treatment is the main treatment. The operative methods include endoscopic therapy, tumor enucleation and partial resection of the esophagus. Endoscopic treatment methods include endoscopic submucosal dissection（ESD） and submucosal tunnelling endoscopic resection（STER）. With the development and maturity of minimally invasive technology, surgical treatment of esophageal GIST is worth further discussion based on the principle of minimal trauma and the best curative effect. In recent years, molecular targeted therapy, including neoadjuvant therapy and postoperative adjuvant therapy, has become a major advance in the treatment of GIST. The success of molecular targeted therapy opens a new era in the molecular targeted therapy of cancer.