血栓通致不良反应病例分析及发生机制探讨

Cases Analysis and Mechanism of 19 Cases of Adverse Drug Reactions Induced by Xueshuantong Injection

目的了解郑州某综合医院血栓通致不良反应(ADR)的一般规律、临床特点及发生原因,为临床合理用药提供参考。方法对医院2013年1月至12月各病区上报的血栓通致ADR 19例患者的资料进行分析,以患者一般情况、给药过程及ADR临床表现等作为考察项,并对其发生机制进行探讨。对患者年龄、性别、ADR发生时间及累及系统分布进行统计学分析。结果血栓通ADR发生率为0.57%,多发生于50岁以上年龄段患者(57.89%,P<0.05);用药首次或再次用药时均可能发生,多发生在用药30 min以内(89.47%);以皮肤及其附件损害(54.54%)为主,且均为新的ADR。结论血栓通致ADR时有发生且作用机制复杂,临床应用时应密切关注患者的病情变化,保证用药安全。

Objective To analyze the clinical characteristics and causes of adverse drug reactions（ ADR） induced by Xueshuantong Injection,and to provide references for the rational drug use.Methods The ordinary circumstances,dosage of sodium,clinical manifestation and the mechanism were analyzed statistically of 19 ADRs induced by Xueshuantong Injection from January to December 2013 of a hospital,and its mechanism was investigated.The age,sex,time distribution and systems involved of the ADRs patients were performed statistical analysis.Results The ADRs rate of Xueshuantong Injection was 0.57%,and 57.89% of the patients were over the age of 50 years old（ P 〈 0.05）.Most patients（ 89.47%） suffered from ADRs in 30 min after administration,and 54.54% were skin reactions（ P 〈 0.05）.All of the cases were new ADRs.Conclusion The adverse reactions induced by Xueshuantong Injection occurred occasionally with complex mechanism,and the patient’s condition changes should pay close attention to in the clinical application,to ensure the safety of medication.