柳州地区亚甲基四氢叶酸还原酶基因多态性与不良妊娠结局的相关性分析

Analysis on the correlation between MTHFR gene polymorphisms and adverse pregnancy outcomes in Liuzhou region

目的探讨柳州地区亚甲基四氢叶酸还原酶(MTHFR)基因多态性与不良妊娠结局的相关性。方法选取2013年10月-2015年4月在柳州市妇幼保健院妇科门诊就诊,曾有不良妊娠结局的260例育龄期女性为病例组,健康早孕的203例育龄期女性为对照组。对MTHFR C677T、A1298C的基因多态性进行分型,并运用统计软件对分布特点进行分析。结果与C677T的CC型相比,携带CT型、TT型和CT+TT型基因型的女性发生不良妊娠结局的风险增高(均P<0.05);与A1298C的AA型相比,携带CC型和AC+CC型不良妊娠结局风险增高(均P<0.05)。结论 MTHFR基因多态性在不良妊娠结局的病理和生理机制中发挥重要作用,携带突变基因会增加发生不良妊娠结局的风险。

Objective To explore the correlation between methylenetetrahydrofolate reductase （MTHFR） gene polymorphisms and ad- verse pregnancy outcomes in Liuzhou region. Methods A total of 260 women of childbearing age with adverse pregnancy outcomes history were selected from the hospital from October 2013 to April 2015 as case group; 203 healthy early pregnant women of childbearing age were selected as control group. MTHFR C677T and A1298C gene polymorphisms were classified, and the distribution characteristics were analyzed by statistical software. Results Compared with the women with C677T CC genotype, the risk of adverse pregnancy outcomes in the women with CT, ＂IT, and CT＋TT genotypes increased significantly （all P〈0. 05） . Compared with the women with A1298C AA genotype, the risk of adverse pregnancy outcomes in the women with CC and AC＋CC increased significantly （ all P〈0.05） . Conclusion MTHFR gene poly- morphisms play important roles in pathological mad physiological mechanism of adverse pregnancy outcomes, carrying the mutant genes may increase the risk of adverse pregnancy outcomes.