变应性鼻炎黏液高分泌的药物治疗新进展

New progress of pharmacotherapy on mucus hypersecretion in allergic rhinitis

黏液高分泌是变应性鼻炎气道慢性炎症的重要病理改变,严重影响人们的工作和生活质量。对变应性鼻炎黏液高分泌的药物治疗靶点包括炎症介质、细胞因子、胆碱能受体、神经肽、介导黏液分泌的信号通路等。本文梳理了变应性鼻炎黏液高分泌治疗药物的研究思路和最新进展,以期为研究者和临床医师提供借鉴。

Mucus hypersecretion is an important physiopathologic change in allergic rhinitis, and seriously affects the quality of work and life. Pharmacotherapy targets for suppression of mucus hypersecretion in allergic rhinitis include： inflammatory mediators, cytokines, muscarinic receptors, neuropeptides, signal pathways of mediating mucus hypersecretion and so on. This article reviewed the research ideas and the latest progress of the research on the treatment of allergic rhinitis mucus hypersecretion, in order to provide reference for the researchers and clinicians.