拟核结合蛋白调控链霉菌形态分化和次级代谢的作用和机制

Streptomyces nucleoid-associated proteins: role in morphological differentiation and secondary metabolism

链霉菌具有独特而复杂的形态分化周期,涉及到染色体复制、浓缩和分离等多个步骤,并伴随着菌丝的分隔和片段化。拟核结合蛋白作为染色体高级结构的重要组成成分,在调控链霉菌的形态分化中发挥了重要作用,调控许多与DNA相关的过程,包括基因表达、DNA保护、重组/修复和拟核的形成与维持等。此外,拟核结合蛋白作为细菌重要的全局性调控因子,也广泛参与了链霉菌次级代谢的调控。本文总结了链霉菌拟核结合蛋白的结构和功能,特别是调控形态分化和次级代谢的最新研究成果。

Streptomyces have a unique and complex morphological differentiation process. The process of aerial hyphae differentiating into spore filaments is accompanied by the biosynthesis of secondary metabolites. The morphological differentiation of Streptomyces involves many steps, such as chromosome replication, condensation and separation. As important components of chromosome structure and the global regulatory factors of bacteria, the nucleoid-associated proteins play an important role in the regulation of morphological differentiation and secondary metabolism of Streptomyces. In this paper, we summarize the structures, functions, regulation of nucleoid-associated proteins and especially their role in morphological differentiation and secondary metabolism of Streptomyces.