摘要
Background Subclinical hypothyroidism is a metabolism disease with elevated thyroid stimulating hormone （TSH） and normal thyroid hormone levels. Patients with subclinical hypothyroidism can have abnormal lipid metabolism, hypertension, coagulation dysfunction, vascular endothelial dysfunction. However, the relationship between subclinical hypothyroidism and cardiovascular events is still uncertain. Methods Prospective studies on the association between subclinical hypothyroidism and coronary heart disease were searched in PubMed, Embase, Wanfang databases and the Cochrane Library. The incidences of coronary heart disease, cardiac death, heart failure and all-cause death were compared between subclinical hypothyroidism group and euthyroidism group. Odds ratios （ORs） with 95% confidence intervals （95% CIs） were used as summary statistics. Results Thirteen eligible studies incorporating 53813 participants were included in this recta-analysis. No significant dif- ferences were found in the comparison of the risk of CHD （9.67% vs. 7.74%, OR=1.09, P=0.19）, cardiac death （7.80% vs. 4.74%, OR=1.34, P=0.06）, all-cause death （13.26% vs. 13.63%, OR=l.05, P=0.77） and heart failure （7.12% vs. 4.29%, OR=1.24, P=0.22） between the subclinical hypothyroidism group and euthyroidism group. Conclusions Our results indicate that subclinical hypothyroidism might not increase the risk of cardio- vascular disease.
Background Subclinical hypothyroidism is a metabolism disease with elevated thyroid stimulating hormone （TSH） and normal thyroid hormone levels. Patients with subclinical hypothyroidism can have abnormal lipid metabolism, hypertension, coagulation dysfunction, vascular endothelial dysfunction. However, the relationship between subclinical hypothyroidism and cardiovascular events is still uncertain. Methods Prospective studies on the association between subclinical hypothyroidism and coronary heart disease were searched in PubMed, Embase, Wanfang databases and the Cochrane Library. The incidences of coronary heart disease, cardiac death, heart failure and all-cause death were compared between subclinical hypothyroidism group and euthyroidism group. Odds ratios （ORs） with 95% confidence intervals （95% CIs） were used as summary statistics. Results Thirteen eligible studies incorporating 53813 participants were included in this recta-analysis. No significant dif- ferences were found in the comparison of the risk of CHD （9.67% vs. 7.74%, OR=1.09, P=0.19）, cardiac death （7.80% vs. 4.74%, OR=1.34, P=0.06）, all-cause death （13.26% vs. 13.63%, OR=l.05, P=0.77） and heart failure （7.12% vs. 4.29%, OR=1.24, P=0.22） between the subclinical hypothyroidism group and euthyroidism group. Conclusions Our results indicate that subclinical hypothyroidism might not increase the risk of cardio- vascular disease.
