痛风清消颗粒急性毒性实验研究

Experimental Study on Acute Toxicity of Tongfeng Qingxiao Granule

目的观察痛风清消颗粒的急性毒性反应,评价其临床用药的安全性。方法采用清洁级昆明种小鼠40只,随机分为2组,分别给予痛风清消颗粒混悬液和生理盐水0.78 ml/次灌胃,24小时内3次,连续观察小鼠的体重、饮食、毒性反应和死亡情况14天。结果 2组小鼠在第1天、第7天和第14天的体重无显著性差异(P>0.05),小鼠一次性口服痛风清消颗粒的最大耐受量为86.88 g durg·kg-1,为成人每日临床常用量的253倍。结论痛风清消颗粒口服临床常用剂量安全。

Objective To evaluate the acute toxicity of Tongfeng Qingxiao granule. Methods The 40 SPF Kun-ming mice were intra- gastrically administrated with 0.78ml mixed suspension of Tongfeng Qingxiao granule or normal saline, respectively, three times in 24 hours, and the weight, diet, toxic reaction and death of mice for 14 days were constantly observed. Results There were no significant differences between two groups in the body weight of mice in 1st, 7th and 14th day （P〉0.05） . The maximum tolerated dose （MTD） of Tongfeng Qingxiao granule of mice is 86.88g durg·kg-1 which is 253 times of clinical adult daily dose. Conclusion Tongfeng Qingxiao granule is safe in the usual clinical dose.