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浅论抗血小板药替格瑞洛遗传药理学和药效学特征的研究进展 被引量:4

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摘要 替格瑞洛属于环戊基三唑嘧啶类口服P2Y12受体拮抗剂,是一种临床应用前景广阔的抗血小板药。临床研究发现,与氯吡格雷等P2Y12受体拮抗剂相比,替格瑞洛经口服后在人体内吸收的速度更快,抗血小板的作用更强,而且无需代谢激活便可起效。此外,替格瑞洛主要由人体的XYP3A4进行分解吸收,因此患者即便使用氯吡格雷等其他P2Y12受体拮抗剂治疗无效,仍可使用替格瑞洛进行治疗。本文论述了临床上对替格瑞洛遗传药理学和药效学特征的研究进展,以便为安全使用替格瑞洛提供参考。
作者 周晶 张海杰
出处 《当代医药论丛》 2017年第7期108-109,共2页
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