老年慢性阻塞性肺疾病病人不同时期TNF-α、IFN-γ、CTGF表达水平分析

Serum levels of TNF-α,IFN-γ and CTGF in different period of chronic obstructive pulmonary disease in elderly patients

目的了解老年慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)不同时期肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、干扰素γ(interferonγ,IFN-γ)和结缔组织生长因子(connective tissue growth factor,CTGF)表达水平及临床意义。方法采集96例老年COPD病人(病例组)治疗前后和同期健康体检者(对照组)空腹血清进行TNF-α、IFN-γ和CTGF水平检测,并进行对比分析。结果病例组治疗前TNF-α、IFN-γ、CTGF水平均显著高于对照组(P<0.05),加重期病人治疗前TNF-α、IFN-γ、CTGF水平均显著高于稳定期病人(P<0.05);病例组治疗8周和16周后的TNF-α、IFN-γ、CTGF水平均显著低于入院前(P<0.05),治疗16周后血清TNF-α、IFN-γ、CTGF水平均显著低于治疗8周后(P<0.05)。结论老年COPD病人血清TNF-α、IFN-γ、CTGF水平升高,急性加重期升高最为明显,TNF-α、IFN-γ、CTGF水平检测对判定COPD病人的病情和评估预后具有一定的临床意义。

Objective To analyze the serum levels of tumor necrosis factor α （TNF-α）, interferon γ（IFN-γ） and cononective tissue growth foactor（CTGF） and its clinical significance in different period of chronic obstructive pulmonary disease（COPD） in elderly patients. Methods The serum levels of TNF- α, IFN-γ and CTGF were measured in 96 patients with COPD （case group） and healthy controls（ control group） in same period before and after treatment. Results The levels of TNF-α, IFN-γ and CTGF in case group were significantly higher than those in control group before treatment （ P〈 0. 05 ） , and they were significantly higher in the exacerbation than those in stable phase （P〈0. 05）. After 8 and 16 weeks of treatment, the levels of TNF-α, IFN-γ and CTGF were significantly decreased （ P〈0.05 ） , while the levels 16 weeks after treatment were significantly lower than those 8 weeks after treatment（ P〈0. 05）. Conclusions The levels of TNF-α, IFN-γ and CTGF in the elderly patients with COPD are significantly higher, espeially in the acute exacerbation. The detection of TNF-α, IFN-γ and CTGF has certain clinical significance in predicting the disease and evaluating the prognosis.