Pentraxin-3、CYFRA21-1、TTF-1的表达与非小细胞肺癌术后早期复发的关系

The Relationship between the Expression of Pentraxin-3,CYFRA21-1,TTF-1 and the Early Postoperative Recurrenceof Non-small Cell Lung Cancer

为了探讨术前血清Pentraxin-3、CYFRA21-1、TTF-1因素与术后早期复发的关系,收集我院胸外科行手术切除治疗的NSCLC患者103例。记录患者性别、年龄、术前血清Pentraxin-3、CYFRA21-1、TTF-1水平、临床分期、肿瘤分化程度、肿瘤直径、组织学类型及术后早期复发情况,并统计分析各因素与术后早期复发的关系。发现早期复发组的术前CYFRA21-1和TTF-1水平要明显高于未复发组,经比较两者之间的差异均具有统计学意义;临床分期、肿瘤分化程度、组织学类型与术后早期复发相关(p<0.05);TTF-1水平及临床分期、肿瘤分化程度与NSCLC术后早期复发相关;TTF-1水平设为42.38 ng/mL时,曲线下面积为0.892(p=0.000);临床分期Ⅰ期、Ⅱ期与Ⅲ期相比较,曲线下面积为0.741(p=0.001);肿瘤分化程度低、中与高相比较,曲线下面积为0.856(p=0.000)。结合我们的研究可以推论,TTF-1水平联合肿瘤分化程度及临床分期可作为NSCLC术后早期复发的标志物。

In order to investigate the relationship between preoperative serum Pentraxin-3, CYFRA21-1, TTF-1 factors and early postoperative recurrence, 103 cases of NSCLC patients treated by surgical resection in Department of thoracic surgery of our hospital were selected. Gender, age, together with preoperative level of s erum Pentraxin-3, CYFRA21-1, TTF-1 of the patients were recorded; Also, clinical staging, tumor differentiation, tumor size, histological type and early postoperative recurrence were recorded, and the relationship between various factors and early recurrence after operation were analyzed. The results showed that the levels of CYFRA21-1 and TTF-1 in early recurrence group were significantly higher than those in the non-recurrence group, and the difference was statistically significant; Clinical stage, degree of tumor differentiation, and histological type were related to early recurrence after surgery （p〈0.05）; TTF-1 level, clinical stage as well as the degree of tumor differentiation were bound up with early recurrence after NSCLC; When the level of TTF-1 was set to 42.38 ng/mL, the area under the curve was 0.892 （p =0.000）; when clinical stage Ⅰ , Ⅱ and Ⅲwere compared, the area under the curve was 0.741 （p=0.001）; When low, middle and high degree of tumor differentiatiation were compared, the area under the curve was 0.856 （p=0.000）. In combination with our study, we could conclude that the level of TTF-1 combined with tumor differentiation and clinical stage could be used as a marker for early postoperative recurrence of NSCLC.