探讨奥美拉唑治疗胃溃疡的药理作用和临床效果

The Pharmacological Clinical Effect of Omeprazole on Gastric Ulcer

本研究将82例胃溃疡患者根据随机数字表分为两组。予以对照组盐酸雷尼替丁治疗,予以观察组奥美拉唑治疗。对比两组治疗前后的疗效及患者IL-2、IL-6、CRP、TNF-α、SOD、VEGF、EGF的水平变化之后,结果发现观察组有效率明显高于对照组,差异有统计学意义(p<0.05);两组治疗前的IL-2、IL-6、CRP水平差异无统计学意义(p>0.05);治疗后的IL-6、CRP水平较治疗前降低,IL-2水平较治疗前升高,且观察组较对照组变化明显(p<0.05);两组治疗前的TNF-α、SOD、VEGF、EGF水平差异无统计学意义(p>0.05);治疗后的TNF-α水平较治疗前降低,SOD、VEGF、EGF水平较治疗前高,且观察组比对照组的变化明显(p<0.05)。提示奥美拉唑在治疗胃溃疡方面效果显著,可改善炎症反应,快速修复溃疡面,是治疗胃溃疡的有效药物。

In this study, 82 cases of gastric ulcer patients were divided into two groups according to the random number table. The control group was treated by ranitidine hydrochloride while the observation group was treated by omeprazole. After comparing the curative effect of two groups and the change of IL-2, IL-6, CRP, TNF alpha, SOD, VEGF, EGF levels before and after treatment, we found that the effective rate of the observation group was obviously higher than that of the control group, and the difference was statistically significant （p 〈0.05）. There were no significant differences between the two groups of IL-2, IL-6, and CRP levels before treatment （p〉0.05）; The levels of IL-6 and CRP after treatment were lower than those before treatment while the level of IL-2 was higher, and the change of the observation group was more obvious than the control group （p〈0.05）. There were no significant differences between the two groups of TNF-α, SOD, VEGF, and EGF levels before treatment （p 〉0.05）; TNF-α levels after treatment was lower than that of pre-treatment, but the SOD, VEGF, and EGF levels were higher than those of pre-treatment and the change of the observation group was more obvious than the control group （p〈0.05）. In conclusion, omeprazole has a remarkable effect on the treatment of gastric ulcer and it is an effective drug for the treatment of gastric ulcer which can improve the inflammatory response and repair ulcer surface quickly.