胆固醇氧化酶最新研究进展

Applications of cholesterol oxidase in biotechnology area

该文综述了胆固醇氧化酶相关研究的最新进展,包括新的微生物来源结构及催化机理研究的进展。在此基础上概述了胆固醇氧化酶在一些领域应用的新进展,包括分析检测害虫控制抗生素合成疾病防治及生物催化转化等方面。目前胆固醇氧化酶研究需要解决的主要问题是酶的辅酶再生及酶的稳定性问题。

The recent advances in the study area of cholesterol oxidases were reported,including new microbial sources, ad- vances on structures and catalytic mechanisms. On this basis, the application of cholesterol oxidase in some fields, such as anal- ysis and detection, pest control, antibiotic synthesis, disease control and biocatalysis, etc. were also summarized. At present, the main problems that need to be solved in the study of cholesterol oxidase is coenzyme regeneration and the instability of the enzyme.