紧密连接与慢性鼻-鼻窦炎发病机制的研究进展

Progress of tight junctions and chronic rhinosinusitis

慢性鼻-鼻窦炎(CRS)是常见的鼻腔鼻窦黏膜炎症性疾病。紧密连接是位于上皮细胞连接的最顶部的连接蛋白复合体,在维持上皮细胞屏障功能上发挥重要的作用。研究表明,紧密连接蛋白缺陷和CRS发病机制存在关联。紧密连接蛋白组成及其与CRS的关系已经成为当前的研究热点,综述其研究进展。

Chronic rhinosinusitis （CRS） is a common inflammatory disease. TJs are the most apically located of the intercellular junctional complexes, and may have critical role in barrier function of epithelium. Found in the recent years, the changes of fight junctions（TJs） may play important roles in the pathogenesis of chronic rhinosinusitis. The component of TJs are the spot-light in current area of research. This review article explores the pathogenesis of CRS, especially the fight junctions, for the sake of further understanding of CRS.