COED-B方案和CHOP方案治疗非霍奇金淋巴瘤的临床比较观察

Clinical Comparison of COED-B Regimen and CHOP Regimen in the Treatment of Non-Hodgkin Lymphoma

目的比较分析COED-B方案和传统CHOP方案治疗非霍奇金淋巴瘤的疗效。方法 84例非霍奇金淋巴瘤患者随机分为COED-B组和CHOP组,COED-B组患者采取COED-B方案化疗,CHOP组患者采取传统CHOP方案化疗,比较分析治疗效果、不良反应以及生存期。结果 COED-B组治疗总有效率(88.1%)显著高于CHOP组(59.5%),差异有统计学意义(P<0.05)。2组患者常见不良反应包括贫血、胃肠道反应、靶细胞降低、脱发等,发生率比较差异均无统计学意义(P均>0.05)。COED-B组1 a生存率显著高于CHOP组,差异有统计学意义(P<0.05);2组患者3、5 a生存率比较差异均无统计学意义(P均>0.05)。COED-B组患者中位无疾病进展时间(6.8个月)显著短于CHOP组(10.4个月),差异有统计学意义(P<0.05)。结论 COED-B方案能够提高非霍奇金淋巴瘤的疗效,具有高效、低毒、经济的特性,对基层医院治疗非霍奇金淋巴瘤有重要意义。

Objective To compare the clinical efficacy of COED-B regimen and traditional CHOP regimen in the treatment of non-Hodgkin lymphoma. Methods Eighty-four patients with non-Hodgkin lymphoma were divided into the COED-B group and the CHOP group,the patients in the COED-B group were taken treatment of COED-B regi- men chemotherapy, the patients in the CHOP group were taken treatment of CHOP regimen chemotherapy, the thera- peutic effect,toxicities and survival of the patients were compared between the two groups. Results The total effi- ciency rate （88.1%） in the COED-B group was significantly higher than that in the CHOP group （59.5%） （P 〈 0.05）. The common toxicities of two groups included anemia, gastrointestinal reactions, reducing the target cells and alopecia. The toxicity incidences was no significant difference between the two groups （P 〉 0.05 ）. The l-year sur- vival rate in the COED-B group was significantly higher than that in the CHOP group （ P 〈 0.05 ） ; the 3-, 5-year survival rates were no significant difference between the two groups （P 〉 0.05 ）. The median progression free time （6.8 months）in the COED-B group was significantly shorter than that in the CHOP group （ 10.4 months） （P 〈0. 05）. Conclusion COED-B regimen can improve the total efficiency of non-Hodgkin lymphoma,which is effec- tive, Xow toxicity and economy.