儿童青少年首发精神分裂症患者认知功能损害与童年创伤的关系

A related study of cognitive impairment and childhood trauma in children and adolescents with first-episode schizophrenia

目的探讨儿童青少年首发精神分裂症患者认知功能损害与童年创伤的关系。方法选取儿童青少年首发精神分裂症患者37例作为研究组,随机抽取23名健康儿童青少年为正常对照组,采用神经认知测验-MATRICS共识认知成套测验(MCCB)分析两组认知功能,采用儿童期成长经历量表(CTQ-SF)评价童年创伤情况。结果研究组MCCB测验的总分及符号编码、语言记忆、空间广度、数字序列、视觉记忆、言语流畅、情绪管理、持续操作分测验评分均低于对照组(P<0.05),连线测验高于对照组(P<0.05)。研究组CTQ-SF的总分及情感虐待、性虐待、躯体忽视因子分高于对照组(P<0.05)。研究组中,无童年创伤的患者MCCB总分高于有童年创伤的患者(P<0.05)。研究组中,MCCB总分与CTQ-SF总分及除情感虐待外的各因子分均呈负相关(P<0.05)。结论儿童青少年首发精神分裂症患者的认知功能损害较为严重,并且与童年创伤程度存在相关性。

Objective To explore the relationship between cognitive impairment and childhood trauma in children and adolescents with first-episode schizophrenia.Method A total of 37 children and adolescents with first-episode schizophrenia in study group and 23 healthy children and adolescents in control group were selected and assessed with MATRICS Consensus Cognitive Battery（MCCB） for cognitive impairment and Childhood Trauma Questionnaire（CTQ-SF） for childhood trauma.Results The total score and factor scores of symbolic coding,language memory,space span,digit sequence,visual memory,verbal fluency,emotion management,continuous operation of MCCB in study group were all significantly lower than those in control group（P〈0.05） and trail making test score of MCCB in study group was significantly higher than that in control group（P〈0.05）.The total score and factor scores of emotional abuse,sexual abuse,physical neglect of CTQ-SF in study group were all significantly higher than those in control group（P〈0.05）.In study group,the total score of MCCB for children and adolescents without childhood trauma was significantly higher than those for children and adolescents with childhood trauma（P〈0.05）.In study group,the total score of MCCB was negatively correlated with the total score and all factor scores（except emotional abuse factor） of CTQ-SF（P〈0.05）.Conclusion It＇s serious for the impairment of cognitive function in children and adolescents with first-episode schizophrenia,which is correlated with the childhood trauma level to some extent.