连续肾脏替代治疗时抗菌药物的剂量调整

Dosing adjustment of antibiotics in continuous renal replacement therapy

急性肾损伤(acute kidney injury,AKI)是严重全身性感染患者的常见临床并发症,其中6%AKI患者需要行连续肾脏替代治疗(continuous renal replacement therapy,CRRT)。AKI本身可影响抗菌药物的药代动力学,而CRRT则使该问题进一步复杂化。根据药代动力学特点,选择抗菌药物类型和剂量,是治疗该病患者的关键。

Acute kidney injury （AKI） is one of the common clinical manifestations in severe sepsis patients, among which 6% patients may need continuous renal replacement therapy （CRRT）. CRRT as well as AKI will affect the pharmacokinetics of antibiotics and eventually affect their clinical effect. The key of antibiotics utilization among those AKI patients is the choice of antibiotics type and dose in the concern of the special pharmacokinetics.