瘦素及其受体在卵巢癌的表达及临床病理特征关系

Expression and clinicopathological features of Leptin and OBR in ovarian cancer

目的研究瘦素(Leptin)及其受体(OBR)在卵巢癌中的表达与临床病理特征的关系。方法利用免疫组化检测102例卵巢癌组织中Leptin及其OBR的表达情况及其与年龄、肿块大小、TMN分期、转移和复发等临床病理特征的相关研究。结果在102例卵巢癌组织中Leptin在卵巢癌组织中的阳性表达率为71.57%;OBR在卵巢癌组织中的阳性表达率为66.67%,两者表达之间无显著性统计学意义(P>0.05)。在卵巢癌组织中Leptin和OBR阳性表达的肿块直径均明显大于其阴性表达,差别有统计学意义(P<0.05)。在卵巢癌Ⅱ/Ⅲ期中Leptin的表达明显高于Ⅰ期(P<0.05)。在Leptin阳性表达时,OBR阳性的肿瘤直径明显大于OBR阴性(P<0.05)。无论Leptin阳性表达与否,OBR阳性表达与肿瘤分期有关(P<0.05)。Leptin和OBR表达与患者年龄、转移、复发和绝经情况无关。结论 Leptin和OBR的表达与卵巢癌肿瘤大小、肿瘤分期有关,Leptin和OBR可能促进卵巢癌细胞的增殖、生长、分化或抑制其凋亡。

Objective To explore the correlation between the clinical features and expressions of leptin and OBR in ovarian cancer. Methods The expressions of leptin and OBR were detected by immunohisto- chemistry （IHC） and researched the relation to clinical pathological characteristics as age, tumor size, TMN staging,metastasis and recurrence in 102 ovarian cancer tissues. Results The positive expression rates of leptin and OBR were 7t. 57% and 65.57% in 102 ovarian cancer tissues. There was not a significant associa- tion between leptin with OBR in ovarian cancer. But ttle tumor size of both positive expression groups of lep- tin and OBR was obviously different with the negative expression groups＇ in ovarian cancer tissues. The differences were significant （ P 〈 0.05 ）. In ovarian cancer ]] /]lI inid-term expression of leptin was obviously higher than that of I period （ P 〈 0.05 ）. While leptin was positive, the tumor size of OBR positive group was obviously lager with the negative＇ s. The OBR expression related to tumor stage whether leptin express or not. And the expression of leptin and OBR was no significant related to age, menopausal status, metastasis and recurrence. Conclusion The expressions of leptin and OBR are maybe association with ovarian tumor size and TMN staging,which accelerat tumor cell proliferation and growth or inhibit the apoptosis.