磷脂酰肌醇蛋白聚糖-3在肝细胞肝癌病理诊断中的价值及应用

The value and application of Glypican-3 in pathological diagnosis of hepatocellular carcinoma

肝细胞肝癌(hepatocellular carcinoma,HCC)的明确诊断主要依靠组织病理学和临床影像学检查,而鉴别诊断需要免疫组化标记物辅助确诊。磷脂酰肌醇蛋白聚糖-3(GPC-3)是一种广泛应用于肝细胞肝癌免疫组化的标记物。随着对GPC-3研究的深入,发现它不仅在血清有表达,同样在肝细胞癌组织中表达。根据GPC-3在肝细胞肝癌及癌旁组织的表达情况,我们更新关于GPC-3在正常和肿瘤组织中的表达的当前知识,评估其在临床实践中作为肿瘤标志物的效用,探讨其作为一种新型癌胚胎蛋白的临床意义,为肝细胞肝癌的诊断提供科学依据,从而为肝细胞肝癌的靶向治疗提供新的方向和依据。

The definitude diagnosis of hepatocellular carcinoma （HCC） is mainly dependent on histopathology and clinical imaging, and the differential diagnosis should be confirmed by immunohistochemical markers. Glypican-3 （ GPC-3 ） is a widely used marker of immunohistochemistry for HCC. With the constant deepening of research on GPC-3 ,it has been found that GPC-3 is not only presented in serum but also expressed in HCC tissues. According to the expression of GPC-3 in HCC and adjacent tissues,we have updated the current knowledge about the expression of GPC-3 in normal and tumor tissues, evaluated its utility as a tumor marker in clinical practice, and investigated the clinical significance of this new type of cancer embryonic protein. This will provide a scientific basis for the diagnosis of HCC, as well a new direction and basis for targeted therapy of HCC.