N-甲基吡咯烷酮作为一碳合成子在曼尼希反应中的应用

Application of N-Methyl-2-pyrrolidinone as One Carbon Synthon in Mannich Reactions

以苯乙酮衍生物为原料,N-甲基吡咯烷酮替代甲醛类似物,考察了其作为一碳合成子在曼尼希反应中的应用。在最优条件下,以46%~93%的收率成功合成了系列曼尼希碱衍生物。该反应底物范围宽泛,官能团兼容性好,并且初步研究了该反应的机理。

With acetophenone derivatives as raw materials, we reported the application of N-methyl-2- pyrrolidone as one carbon synthon to replace formaldehyde analogues in the Mannich reaction. Under optimal reaction conditions, a series of mannich base derivatives were obtained with 46% ~ 93% yield. This reaction shows a broad substrate scope and good functional groups compatibility. The preliminary mechanism of the reaction was also studied.