白细胞介素-1β基因T-31C多态性与牙周炎易感性的Meta分析

Meta-Analysis of Association Between Interleukin-1β T-31C Polymorphism and Chronic Periodontitis Susceptibility

目的:应用Meta分析的方法评价白细胞介素-1β(IL-1β)基因T-31C多态性与牙周炎易感性之间的关系。方法:全面检索PubMed、Embase和中国知网,检索时间截至2016年5月26日。由2位研究者独立筛选文献和提取数据后,采用Comprehensive Meta-Analysis v2软件进行Meta分析。结果:最终纳入8项病例-对照研究,结果显示5种基因模型均未发现IL-1β基因T-31C多态性与牙周炎易感性之间存在相关性。敏感性分析证实总体结果稳健性良好,亚组分析与总体研究的结果也基本一致。结论:当前证据尚不能证实IL-1β基因T-31C多态性与牙周炎易感性之间存在相关性。

Objective：To investigate the association between interleukin-1β（IL-1β）T-31 Cpolymorphism and periodontitis risk using a meta-analysis.Methods：A comprehensive literature search from PubMed,Embase and Chinese National Knowledge Infrastructure up to May 26,2016 was made.Two authors selected the studies and extracted data,and then the meta-analysis was conducted using the Comprehensive Meta-Analysis v2 software.Results：Finally eight case-control studies were yielded.All five genetic models revealed non-significant association between the IL-1βT-31 Cpolymorphism and periodontitis risk.Sensitivity analysis indicated that the results were robust and the subgroup analysis yielded similar results.Conclusion：Based on current evidence,the IL-1βT-31 C polymorphism was not associated with PD susceptibility in overall population.