成纤维细胞生长因子6(FGF6)的研究进展

The Progression of Fibroblast Growth Factor 6

成纤维细胞生长因子6(fibroblast growth factor 6,FGF6)是成纤维细胞生长因子家族(FGFs)的成员之一,主要通过与酪氨酸激酶受体(fibroblast growth factor receptor,FGFR)1和4结合发挥其生物学活性。研究发现,人FGF6几乎都积聚在肌源性细胞系中,参与肌源性细胞系的增殖及分化,在肌肉修复和再生过程中起重要作用,同时它还是一个重要的调节骨生成和骨重建的因子;FGF6在心脏中也有表达,进一步试验结果表明其具有促进心肌细胞增殖及保护心肌细胞凋亡的作用;在成体睾丸和乳腺癌中也检测到有FGF6的转录物,表明其在肿瘤发生发展中的作用。目前,FGF6在多种疾病中的功能和相关机制仍有待进一步研究和确认,但其所具备的生物学活性尤其是在肌肉再生方面具有重要的意义和巨大的应用潜力。

Fibroblast growth factor 6 （FGF6） is a member of the fibroblast growth factor family （ FGFs）, induces a transduction signal preferentially via FGFR1 and FGFR4. It has been found, the human FGF6 participates in the proliferation and differentiation of muscle-derived cell lines, accumulated almost exclusively in the myogenic lineage, playing an important role in muscle repair and regeneration. At the same time, FGF6 is an important regulator of bone formation and bone remodeling; it also expressed in the heart, indicating that it can promote myocardial cell proliferation and protect the apoptosis of myocardial cells; in the adult testis FGF6 transcript is also detected, indicating that it plays a role in prostate cancer. At present, it remained to be further studied and confirmed the function and the related mechanisms of FGF6 in a variety of diseases, but its biological activity especially in muscle regeneration has important significance and great potential application.