江苏产菲律宾蛤仔提取物的抗疲劳作用

Anti-Fatigue Effect of the Extract from Ruditapes philippinarum Cultivated in Jiangsu Province

研究了江苏产菲律宾蛤仔提取物(RE)对运动小鼠抗疲劳能力的影响。将小鼠随机分为6组,正常组、模型组、阳性组以及低、中、高3个剂量组。小鼠灌胃15 d后,采用小鼠游泳疲劳模型,观察各组小鼠负重游泳时间、不负重游泳后血清乳酸(LA)、尿素氮(BUN)、肌酸激酶(CK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)指标的差异。结果:高、中剂量组小鼠负重游泳时间明显长于模型组和低剂量组;与模型组相比,3个剂量组小鼠血清乳酸(p<0.01)含量显著降低,且呈剂量依赖性;肌酸激酶(p<0.01)、乳酸脱氢酶(p<0.01)活力均下降,超氧化物歧化酶(p<0.05)活力升高,尿素氮含量仅高剂量有显著性差异。结论:菲律宾蛤仔提取物能提高小鼠运动耐力,加速疲劳的消除。

The study aimed to investigate the in vivo anti-fatigue effect of an extract from Ruditapes philippinarum. Mice were randomly divided into six groups （normal,mode,positive,three dose groups） and after oral administration for 15 days,the forced swimming models of mice were established. The swimming time with weight loading was recorded and contents of lactic acid （LA） and blood urea nitrogen （BUN） and activities of lactate dehydrogenase （LDH）, creatine kinase （CK） and superoxide dismutase （SOD） in mice serum were analyzed. Results showed that the swimming time of high and medium doses of groups with weight loading was longer than that of the mode group,three dose groups after exercise had an obviously reduced content of LA （p〈0.01）,a lower content of BUN,a higher activity of SOD （p〈0.05）,and lower activities of LDH （p〈0.01） and CK （p〈0.01）. Thus,the extract from Ruditapes philippinarum could be effective in accelerating the decomposition of metabolites to delay fatigue.